Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149446263> ?p ?o ?g. }
- W2149446263 endingPage "228" @default.
- W2149446263 startingPage "223" @default.
- W2149446263 abstract "The retinoid receptors have major roles throughout development, even in the absence of ligand. Here, we summarize an emerging theme whereby gene repression, mediated by unliganded retinoid receptors, can dictate cell fate. In addition to activating transcription, retinoid receptors actively repress gene transcription by recruiting cofactors that promote chromatin compaction. Two developmental processes for which gene silencing by the retinoid receptors is essential are head formation in Xenopus and skeletal development in the mouse. Inappropriate repression, by oncogenic retinoic acid (RA)**Abbreviations used in this paper: APL, acute promyelocytic leukemia; dnRARalpha, dominant-negative version of the RARalpha; E, embryonic age; HDAC, histone deacetylase; LCoR, ligand-dependent corepressor; NCoR, nuclear receptor corepressor; RA, retinoic acid; RAR, RA receptor; RARE, RXR homodimer bound to bipartite response element; RXR, retinoid X receptor; TSA, trichostatin A; CYP26, cytochrome p450, 26; TR, thyroid hormone receptor. receptor (RAR) fusion proteins, blocks myeloid differentiation leading to a rare form of leukemia. Our current understanding of the developmental role of retinoid repression and future perspectives in this field are discussed." @default.
- W2149446263 created "2016-06-24" @default.
- W2149446263 creator A5019107328 @default.
- W2149446263 creator A5057227412 @default.
- W2149446263 creator A5085628229 @default.
- W2149446263 date "2003-04-28" @default.
- W2149446263 modified "2023-09-23" @default.
- W2149446263 title "Active repression by unliganded retinoid receptors in development" @default.
- W2149446263 cites W1553857166 @default.
- W2149446263 cites W1841957993 @default.
- W2149446263 cites W1906119900 @default.
- W2149446263 cites W1910848366 @default.
- W2149446263 cites W1974545855 @default.
- W2149446263 cites W1976271397 @default.
- W2149446263 cites W1983547790 @default.
- W2149446263 cites W1986457767 @default.
- W2149446263 cites W1986864689 @default.
- W2149446263 cites W1989867979 @default.
- W2149446263 cites W1991934631 @default.
- W2149446263 cites W1992513785 @default.
- W2149446263 cites W2005647333 @default.
- W2149446263 cites W2006602286 @default.
- W2149446263 cites W2017087879 @default.
- W2149446263 cites W2026118162 @default.
- W2149446263 cites W2027297574 @default.
- W2149446263 cites W2028512350 @default.
- W2149446263 cites W2030495641 @default.
- W2149446263 cites W2030928908 @default.
- W2149446263 cites W2036912330 @default.
- W2149446263 cites W2052306126 @default.
- W2149446263 cites W2055573396 @default.
- W2149446263 cites W2057254334 @default.
- W2149446263 cites W2062278718 @default.
- W2149446263 cites W2069532898 @default.
- W2149446263 cites W2074786828 @default.
- W2149446263 cites W2075377162 @default.
- W2149446263 cites W2089357779 @default.
- W2149446263 cites W2091376202 @default.
- W2149446263 cites W2091508315 @default.
- W2149446263 cites W2097724305 @default.
- W2149446263 cites W2099407461 @default.
- W2149446263 cites W2102611655 @default.
- W2149446263 cites W2105106545 @default.
- W2149446263 cites W2105184204 @default.
- W2149446263 cites W2110136415 @default.
- W2149446263 cites W2111686546 @default.
- W2149446263 cites W2125601003 @default.
- W2149446263 cites W2126158230 @default.
- W2149446263 cites W2126602684 @default.
- W2149446263 cites W2132837491 @default.
- W2149446263 cites W2136317649 @default.
- W2149446263 cites W2136879986 @default.
- W2149446263 cites W2138094668 @default.
- W2149446263 cites W2140316723 @default.
- W2149446263 cites W2141568746 @default.
- W2149446263 cites W2156575042 @default.
- W2149446263 cites W2158334888 @default.
- W2149446263 cites W2166256370 @default.
- W2149446263 cites W2170167935 @default.
- W2149446263 cites W2171716250 @default.
- W2149446263 cites W2275405376 @default.
- W2149446263 cites W2312235522 @default.
- W2149446263 cites W2323921384 @default.
- W2149446263 cites W2398364572 @default.
- W2149446263 cites W2412551544 @default.
- W2149446263 cites W2893539009 @default.
- W2149446263 cites W4248318091 @default.
- W2149446263 doi "https://doi.org/10.1083/jcb.200211117" @default.
- W2149446263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2172895" @default.
- W2149446263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12719467" @default.
- W2149446263 hasPublicationYear "2003" @default.
- W2149446263 type Work @default.
- W2149446263 sameAs 2149446263 @default.
- W2149446263 citedByCount "122" @default.
- W2149446263 countsByYear W21494462632012 @default.
- W2149446263 countsByYear W21494462632013 @default.
- W2149446263 countsByYear W21494462632014 @default.
- W2149446263 countsByYear W21494462632015 @default.
- W2149446263 countsByYear W21494462632016 @default.
- W2149446263 countsByYear W21494462632017 @default.
- W2149446263 countsByYear W21494462632018 @default.
- W2149446263 countsByYear W21494462632019 @default.
- W2149446263 countsByYear W21494462632020 @default.
- W2149446263 countsByYear W21494462632021 @default.
- W2149446263 countsByYear W21494462632022 @default.
- W2149446263 countsByYear W21494462632023 @default.
- W2149446263 crossrefType "journal-article" @default.
- W2149446263 hasAuthorship W2149446263A5019107328 @default.
- W2149446263 hasAuthorship W2149446263A5057227412 @default.
- W2149446263 hasAuthorship W2149446263A5085628229 @default.
- W2149446263 hasBestOaLocation W21494462631 @default.
- W2149446263 hasConcept C104317684 @default.
- W2149446263 hasConcept C128821507 @default.
- W2149446263 hasConcept C146777309 @default.
- W2149446263 hasConcept C162253465 @default.
- W2149446263 hasConcept C502942594 @default.
- W2149446263 hasConcept C54355233 @default.
- W2149446263 hasConcept C63932345 @default.