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- W2149447351 abstract "Mosier et al. (1) have demonstrated that EBVcarrying lymphoproliferative disease (LPD) occurs in mice with severe combined immunodeficiency disease (SCID) following engraftment with 5 to 7x 10’ peripheral blood leukocytes (PBL) within 12 weeks following intraperitoneal (i.p.) inoculation. In the present study, we sought to charac-terize more fully the clonality of the LPD using immuno-histochemical and molecular techniques. Secondly, we compared the clonality of the LPD in mice inoculated with PBL from seropositive individuals compared to seronegative donors. The latter engrafted mice were inoculated with B95–8 virus. Thirdly, our studies compared the engraftment of PBL from normal donors to that from patients with X-linked lymphoproliferative disease (XLP) who are exquisitely vulnerable to the virus (2)." @default.
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- W2149447351 date "1991-01-01" @default.
- W2149447351 modified "2023-10-01" @default.
- W2149447351 title "Scid Mouse Model of Virus-Induced Lymphomagenesis of Immunodeficient Humans" @default.
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- W2149447351 doi "https://doi.org/10.1007/978-1-4612-0405-3_43" @default.
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