FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149449623> ?p ?o ?g. }

• W2149449623 endingPage "7437" @default.
• W2149449623 startingPage "7427" @default.
• W2149449623 abstract "Abstract Purpose: The purpose of this study was to determine the role of functional interactions between pancreatic cancer cells and pancreatic stellate cells (PSCs) in the formation of the desmoplastic reaction (DR) in pancreatic cancer and to characterize the effect of type I collagen (the predominant component of the DR) on pancreatic cancer cell phenotype. Experimental Design: PSCs and type I collagen were identified in sections of pancreatic cancer using immunohistochemistry, and their anatomic relationship was studied. Interactions among pancreatic cancer cell lines (MIA PaCa-2, Panc-1, and AsPC-1), primary cultures of human PSCs, and type I collagen were investigated in a series of tissue culture models. Results: In vivo, the DR causes gross distortion of normal pancreas, bringing cancer cells into close contact with numerous PSCs and abundant type I collagen. In tissue culture models of pancreatic cancer, conditioned media from each cell line increased PSC [3H]thymidine incorporation up to 6.3-fold that of controls, and AsPC-1 cells also increased PSC collagen synthesis 1.3-fold. Type I collagen was observed to increase long-term survival of pancreatic cancer cells treated with 5-fluorouracil, by up to 62% in clonogenic assays. This was because type I collagen increased the proliferation of cancer cells ([3H]thymidine incorporation was up to 2.8-fold that of cells cultured on tissue culture plastic) and reduced apoptosis of AsPC-1 cells in response to 5-fluorouracil (by regulating mcl-1). Conclusions: These experiments elucidate a mechanism by which the DR in pancreatic cancer may form and, via the collagen within it, promote the malignant phenotype of pancreatic cancer cells, suggesting significant detriment to the host." @default.
• W2149449623 created "2016-06-24" @default.
• W2149449623 creator A5005486613 @default.
• W2149449623 creator A5006864180 @default.
• W2149449623 creator A5020908496 @default.
• W2149449623 creator A5029141413 @default.
• W2149449623 creator A5033566588 @default.
• W2149449623 creator A5040740891 @default.
• W2149449623 creator A5042824194 @default.
• W2149449623 creator A5045582236 @default.
• W2149449623 creator A5058567615 @default.
• W2149449623 date "2004-11-01" @default.
• W2149449623 modified "2023-10-18" @default.
• W2149449623 title "Type I Collagen Promotes the Malignant Phenotype of Pancreatic Ductal Adenocarcinoma" @default.
• W2149449623 cites W1512072225 @default.
• W2149449623 cites W1529267387 @default.
• W2149449623 cites W1656339735 @default.
• W2149449623 cites W1907686361 @default.
• W2149449623 cites W1972325477 @default.
• W2149449623 cites W1979123513 @default.
• W2149449623 cites W1985268528 @default.
• W2149449623 cites W1989052616 @default.
• W2149449623 cites W1989732890 @default.
• W2149449623 cites W1991827918 @default.
• W2149449623 cites W1993083123 @default.
• W2149449623 cites W1994411692 @default.
• W2149449623 cites W2007099293 @default.
• W2149449623 cites W2018371450 @default.
• W2149449623 cites W2024548886 @default.
• W2149449623 cites W2027550738 @default.
• W2149449623 cites W2040521623 @default.
• W2149449623 cites W2048824773 @default.
• W2149449623 cites W2051543380 @default.
• W2149449623 cites W2063659536 @default.
• W2149449623 cites W2075440751 @default.
• W2149449623 cites W2075542566 @default.
• W2149449623 cites W2078818685 @default.
• W2149449623 cites W2081740630 @default.
• W2149449623 cites W2089787303 @default.
• W2149449623 cites W2091314328 @default.
• W2149449623 cites W2099069267 @default.
• W2149449623 cites W2108244474 @default.
• W2149449623 cites W2109482775 @default.
• W2149449623 cites W2145021060 @default.
• W2149449623 cites W2147355261 @default.
• W2149449623 cites W2155510164 @default.
• W2149449623 cites W2163077761 @default.
• W2149449623 cites W2164407945 @default.
• W2149449623 cites W2169970968 @default.
• W2149449623 cites W2336678768 @default.
• W2149449623 cites W344608338 @default.
• W2149449623 doi "https://doi.org/10.1158/1078-0432.ccr-03-0825" @default.
• W2149449623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15534120" @default.
• W2149449623 hasPublicationYear "2004" @default.
• W2149449623 type Work @default.
• W2149449623 sameAs 2149449623 @default.
• W2149449623 citedByCount "260" @default.
• W2149449623 countsByYear W21494496232012 @default.
• W2149449623 countsByYear W21494496232013 @default.
• W2149449623 countsByYear W21494496232014 @default.
• W2149449623 countsByYear W21494496232015 @default.
• W2149449623 countsByYear W21494496232016 @default.
• W2149449623 countsByYear W21494496232017 @default.
• W2149449623 countsByYear W21494496232018 @default.
• W2149449623 countsByYear W21494496232019 @default.
• W2149449623 countsByYear W21494496232020 @default.
• W2149449623 countsByYear W21494496232021 @default.
• W2149449623 countsByYear W21494496232022 @default.
• W2149449623 countsByYear W21494496232023 @default.
• W2149449623 crossrefType "journal-article" @default.
• W2149449623 hasAuthorship W2149449623A5005486613 @default.
• W2149449623 hasAuthorship W2149449623A5006864180 @default.
• W2149449623 hasAuthorship W2149449623A5020908496 @default.
• W2149449623 hasAuthorship W2149449623A5029141413 @default.
• W2149449623 hasAuthorship W2149449623A5033566588 @default.
• W2149449623 hasAuthorship W2149449623A5040740891 @default.
• W2149449623 hasAuthorship W2149449623A5042824194 @default.
• W2149449623 hasAuthorship W2149449623A5045582236 @default.
• W2149449623 hasAuthorship W2149449623A5058567615 @default.
• W2149449623 hasConcept C117262875 @default.
• W2149449623 hasConcept C121608353 @default.
• W2149449623 hasConcept C126322002 @default.
• W2149449623 hasConcept C134018914 @default.
• W2149449623 hasConcept C142724271 @default.
• W2149449623 hasConcept C176891718 @default.
• W2149449623 hasConcept C185592680 @default.
• W2149449623 hasConcept C190283241 @default.
• W2149449623 hasConcept C2778764654 @default.
• W2149449623 hasConcept C2780210213 @default.
• W2149449623 hasConcept C2780644872 @default.
• W2149449623 hasConcept C2781182431 @default.
• W2149449623 hasConcept C502942594 @default.
• W2149449623 hasConcept C54355233 @default.
• W2149449623 hasConcept C55493867 @default.
• W2149449623 hasConcept C71924100 @default.
• W2149449623 hasConcept C81885089 @default.
• W2149449623 hasConcept C86803240 @default.
• W2149449623 hasConcept C96232424 @default.

• next