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- W2149457988 abstract "Adjuvant arthritis (AA) serves as an excellent model for human rheumatoid arthritis. AA is readily inducible in certain rat strains, but not in others. Susceptibility/resistance to AA is determined by multiple factors. Among the genetic factors, both MHC and non-MHC genes contribute to arthritis susceptibility, and specific quantitative trait loci show association with the severity of the disease. Differential T-cell proliferative and cytokine responses, as well as antibody responses, to heat-shock proteins are evident when comparing AA-susceptible and AA-resistant rats. In addition, neuroendocrine factors and the housing environment can further modulate arthritis susceptibility/severity in particular rat strains." @default.
- W2149457988 created "2016-06-24" @default.
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- W2149457988 date "2009-01-01" @default.
- W2149457988 modified "2023-10-10" @default.
- W2149457988 title "The determinants of susceptibility/resistance to adjuvant arthritis in rats" @default.
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- W2149457988 doi "https://doi.org/10.1186/ar2755" @default.
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