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- W2149459352 abstract "A series of rats was subjected to subconvulsant and convulsant doses of pentylenetetrazol (PTZ) and the brains were examined electronmicroscopically. After establishing baseline dose effects, rats were chronically implanted bilaterally with cortical bipolar electrodes in frontal and parietal regions. One week postoperatively, they received on either 3 or 4 successive days subconvulsant doses (10 to 20 mg/kg) of PTZ. The following electroclinical evolution was characteristic: Focal spike activity in some of the sampled regions was followed by asymptomatic low-voltage “spike-wave” bursts, which were in turn followed by higher voltage more diffuse “spike-wave” bursts associated with whisker twitching. The animals were killed on the third, fourth, or fifth day when the full clinical picture was present, but before a generalized convulsive seizure had occurred. Electron micrographs showed swollen glial processes around capillaries. No change could be detected in the endothelial basement membrane and the neurons appeared intact. We conclude that ultrastructural changes can be demonstrated prior to overt major seizures and that they are similar to some results in the literature on animals which received convulsant doses. Repeated subconvulsant doses of PTZ also led to a “kindling” effect." @default.
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- W2149459352 date "1979-05-01" @default.
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- W2149459352 title "Electroclinical and ultrastructural changes associated with subconvulsant doses of pentylenetetrazol" @default.
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- W2149459352 doi "https://doi.org/10.1016/0014-4886(79)90278-4" @default.
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