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- W2149459712 abstract "Reporter gene expression in the olfactory epithelium of H- lacZ 6 transgenic mice mimics the cell-selective expression pattern known for some odorant receptor genes. The transgene construct in these mice consists of the lacZ coding region, driven by the proximal olfactory marker protein ( OMP ) gene promoter, and shows expression in a zonally confined subpopulation of olfactory neurons. To address mechanisms underlying the odorant receptor-like expression pattern of the lacZ construct, we analyzed the transgene-flanking region and identified OR-Z6 , the first cloned odorant receptor gene that maps to mouse chromosome 6. OR-Z6 bears the highest sequence similarity (85%) to a human odorant receptor gene at the syntenic location on human chromosome 7. We analyzed the expression pattern of OR-Z6 in olfactory tissues of H- lacZ 6 mice and show that it bears strong similarities to that mapped for β-galactosidase. Expression of both genes in olfactory neurons is primarily restricted to the same medial subregion of the olfactory epithelium. Axons from both neuronal subpopulations project to the same ventromedial aspect of the anterior olfactory bulbs. Furthermore, colocalization analyses in H- lacZ 6 mice demonstrate that OR-Z6 -reactive glomeruli receive axonal input from lacZ -positive neurons as well. These results suggest that the expression of both genes is coordinated and that transgene expression in H- lacZ 6 mice is regulated by locus-dependent mechanisms." @default.
- W2149459712 created "2016-06-24" @default.
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- W2149459712 date "2001-07-01" @default.
- W2149459712 modified "2023-09-27" @default.
- W2149459712 title "The<i>OMP–lacZ</i>Transgene Mimics the Unusual Expression Pattern of<i>OR-Z6</i>, a New Odorant Receptor Gene on Mouse Chromosome 6: Implication for Locus-Dependent Gene Expression" @default.
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- W2149459712 doi "https://doi.org/10.1523/jneurosci.21-13-04637.2001" @default.
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