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• W2149461102 abstract "Hydrogen sulfide (H₂S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes—cystathionine-<i>β</i>-synthase (CBS), cystathionine-<i>γ</i>-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase—and its levels increase under inflammatory conditions or sepsis. Since H₂S and H₂S-releasing molecules afford inhibitory properties in leukocyte trafficking, we tested whether endogenous annexin A1 (AnxA1), a glucocorticoid-regulated inhibitor of inflammation acting through formylated-peptide receptor 2 (ALX), could display intermediary functions in the anti-inflammatory profile of H₂S. We first investigated whether endogenous AnxA1 could modulate H₂S biosynthesis. To this end, a marked increase in CBS and/or CSE gene products was quantified by quantitative real-time polymerase chain reaction in aortas, kidneys, and spleens collected from AnxA1^−/− mice, as compared with wild-type animals. When lipopolysaccharide-stimulated bone marrow–derived macrophages were studied, H₂S-donor sodium hydrosulfide (NaHS) counteracted the increased expression of inducible nitric oxide synthase and cyclooxygenase 2 mRNA evoked by the endotoxin, yet it was inactive in macrophages harvested from AnxA1^−/− mice. Next we studied the effect of in vivo administration of NaHS in a model of interleukin-1<i>β</i> (IL-1<i>β</i>)–induced mesenteric inflammation. AnxA1^+/+ mice treated with NaHS (100 <i>μ</i>mol/kg) displayed inhibition of IL-1<i>β</i>–induced leukocyte adhesion/emigration in the inflamed microcirculation, not observed in AnxA1^−/− animals. These results were translated by testing human neutrophils, where NaHS (10–100 <i>μ</i>M) prompted an intense mobilization (>50%) of AnxA1 from cytosol to cell surface, an event associated with inhibition of cell/endothelium interaction under flow. Taken together, these data strongly indicate the existence of a positive interlink between AnxA1 and H₂S pathway, with nonredundant functions in the control of experimental inflammation." @default.
• W2149461102 created "2016-06-24" @default.
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• W2149461102 date "2014-07-30" @default.
• W2149461102 modified "2023-09-29" @default.
• W2149461102 title "Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation" @default.
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• W2149461102 doi "https://doi.org/10.1124/jpet.114.217034" @default.
• W2149461102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256431" @default.
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