FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149461144> ?p ?o ?g. }

• W2149461144 abstract "In extracts from vegetative Dictyostelium discoideum V12 the basal NAD-dependent glutamate dehydrogenase (NAD-GDH) activity was low, but it increased on standing at 4 degrees C. When 0.1 mM-AMP was included in the assay mix, enzyme activity was stimulated nearly 30-fold. As the extract was allowed to age, the enzyme rapidly lost its ability to be stimulated by AMP. The response of NAD-GDH to AMP was also dependent on the stage of morphogenesis. The ratios of NAD-GDH activity assayed with and without AMP (+AMP/-AMP ratios) in freshly prepared extracts from cells at 0, 4, 8 and 12 h of development were similar, but declined later in morphogenesis. The +AMP/-AMP ratio decreased sharply during activation at 4 degrees C in extracts from cells at 0, 4, 16 and 20 h of development. By contrast, extracts from cells starved for 8 and 12 h remained more responsive to AMP throughout activation. Analysis of Western blots showed that vegetative NAD-GDH did not undergo any detectable proteolytic cleavage during 96 h of activation at 4 degrees C. Also, no change in molecular mass appeared to take place within the cells until culmination (20-24 h), when some breakdown products appeared. Activation of NAD-GDH also occurred in D. discoideum strains NC4 and AX3, and in D. mucoroides. In addition, the enzyme from these four strains was stimulated by AMP and the +AMP/-AMP ratio declined with similar kinetics during activation. The enzyme from Polysphondylium violaceum was not activated on standing, but it was stimulated by AMP. The effect of activation of NAD-GDH is discussed in relation to a postulated catabolic role for this enzyme." @default.
• W2149461144 created "2016-06-24" @default.
• W2149461144 creator A5009626848 @default.
• W2149461144 creator A5081089644 @default.
• W2149461144 date "1992-09-01" @default.
• W2149461144 modified "2023-10-16" @default.
• W2149461144 title "The effect of AMP on the NAD-dependent glutamate dehydrogenase during activation and morphogenesis in the cellular slime moulds" @default.
• W2149461144 cites W1147879691 @default.
• W2149461144 cites W1499814836 @default.
• W2149461144 cites W1506664443 @default.
• W2149461144 cites W1538552583 @default.
• W2149461144 cites W1542350928 @default.
• W2149461144 cites W1557712139 @default.
• W2149461144 cites W1593607906 @default.
• W2149461144 cites W2004840814 @default.
• W2149461144 cites W2010903824 @default.
• W2149461144 cites W2015425620 @default.
• W2149461144 cites W2029286916 @default.
• W2149461144 cites W2034441496 @default.
• W2149461144 cites W2052831047 @default.
• W2149461144 cites W2058331105 @default.
• W2149461144 cites W2065358750 @default.
• W2149461144 cites W2070449775 @default.
• W2149461144 cites W2073711204 @default.
• W2149461144 cites W2080594377 @default.
• W2149461144 cites W2082627137 @default.
• W2149461144 cites W2086072638 @default.
• W2149461144 cites W2089582398 @default.
• W2149461144 cites W2093441898 @default.
• W2149461144 cites W2100837269 @default.
• W2149461144 cites W2100929308 @default.
• W2149461144 cites W2128635872 @default.
• W2149461144 cites W2154342362 @default.
• W2149461144 cites W2160673923 @default.
• W2149461144 cites W2162142215 @default.
• W2149461144 cites W2214447253 @default.
• W2149461144 cites W2277008478 @default.
• W2149461144 cites W2415201210 @default.
• W2149461144 cites W2469221717 @default.
• W2149461144 doi "https://doi.org/10.1099/00221287-138-9-1935" @default.
• W2149461144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1402793" @default.
• W2149461144 hasPublicationYear "1992" @default.
• W2149461144 type Work @default.
• W2149461144 sameAs 2149461144 @default.
• W2149461144 citedByCount "8" @default.
• W2149461144 crossrefType "journal-article" @default.
• W2149461144 hasAuthorship W2149461144A5009626848 @default.
• W2149461144 hasAuthorship W2149461144A5081089644 @default.
• W2149461144 hasBestOaLocation W21494611441 @default.
• W2149461144 hasConcept C104317684 @default.
• W2149461144 hasConcept C153911025 @default.
• W2149461144 hasConcept C170493617 @default.
• W2149461144 hasConcept C181199279 @default.
• W2149461144 hasConcept C2775969001 @default.
• W2149461144 hasConcept C2776317432 @default.
• W2149461144 hasConcept C2777202666 @default.
• W2149461144 hasConcept C40692019 @default.
• W2149461144 hasConcept C45566312 @default.
• W2149461144 hasConcept C55493867 @default.
• W2149461144 hasConcept C61174792 @default.
• W2149461144 hasConcept C75520062 @default.
• W2149461144 hasConcept C86803240 @default.
• W2149461144 hasConceptScore W2149461144C104317684 @default.
• W2149461144 hasConceptScore W2149461144C153911025 @default.
• W2149461144 hasConceptScore W2149461144C170493617 @default.
• W2149461144 hasConceptScore W2149461144C181199279 @default.
• W2149461144 hasConceptScore W2149461144C2775969001 @default.
• W2149461144 hasConceptScore W2149461144C2776317432 @default.
• W2149461144 hasConceptScore W2149461144C2777202666 @default.
• W2149461144 hasConceptScore W2149461144C40692019 @default.
• W2149461144 hasConceptScore W2149461144C45566312 @default.
• W2149461144 hasConceptScore W2149461144C55493867 @default.
• W2149461144 hasConceptScore W2149461144C61174792 @default.
• W2149461144 hasConceptScore W2149461144C75520062 @default.
• W2149461144 hasConceptScore W2149461144C86803240 @default.
• W2149461144 hasLocation W21494611441 @default.
• W2149461144 hasLocation W21494611442 @default.
• W2149461144 hasOpenAccess W2149461144 @default.
• W2149461144 hasPrimaryLocation W21494611441 @default.
• W2149461144 hasRelatedWork W1998283797 @default.
• W2149461144 hasRelatedWork W1999329926 @default.
• W2149461144 hasRelatedWork W2013996001 @default.
• W2149461144 hasRelatedWork W2026068628 @default.
• W2149461144 hasRelatedWork W2033494319 @default.
• W2149461144 hasRelatedWork W2035650911 @default.
• W2149461144 hasRelatedWork W2054255815 @default.
• W2149461144 hasRelatedWork W2078646031 @default.
• W2149461144 hasRelatedWork W2085598782 @default.
• W2149461144 hasRelatedWork W2149461144 @default.
• W2149461144 isParatext "false" @default.
• W2149461144 isRetracted "false" @default.
• W2149461144 magId "2149461144" @default.
• W2149461144 workType "article" @default.