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- W2149462563 abstract "Lynch syndrome (LS) is caused by a germline mutation in one of the mismatch repair (MMR) genes. The resulting loss of MMR gene function induces a strong mutator phenotype and predisposition to colorectal cancer (CRC). LS mutation carriers undergo regular colonoscopic surveillance and have extensive colonic resection in case of cancer because of the chance of metachronous tumors. Given the high risk and early onset of CRC, LS mutation carriers are good candidates for chemoprevention. Furthermore, evidence increases indicating that the response of MMR-deficient tumors to standard chemotherapy and radiotherapy differs from that of MMR-proficient tumors. Efforts should thus be directed at designing tailored strategies concerning both chemoprevention and medical cancer treatment for LS individuals. This review provides guidance for future studies in this field based on results from clinical and preclinical research." @default.
- W2149462563 created "2016-06-24" @default.
- W2149462563 creator A5013384569 @default.
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- W2149462563 creator A5051509827 @default.
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- W2149462563 creator A5056419521 @default.
- W2149462563 creator A5061495577 @default.
- W2149462563 creator A5074534013 @default.
- W2149462563 date "2011-11-01" @default.
- W2149462563 modified "2023-09-27" @default.
- W2149462563 title "Perspectives for tailored chemoprevention and treatment of colorectal cancer in Lynch syndrome" @default.
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