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• W2149463911 startingPage "e1003526" @default.
• W2149463911 abstract "The highly conserved, Nxf/Nxt (TAP/p15) RNA nuclear export pathway is important for export of most mRNAs from the nucleus, by interacting with mRNAs and promoting their passage through nuclear pores. Nxt1 is essential for viability; using a partial loss of function allele, we reveal a role for this gene in tissue specific transcription. We show that many Drosophila melanogaster testis-specific mRNAs require Nxt1 for their accumulation. The transcripts that require Nxt1 also depend on a testis-specific transcription complex, tMAC. We show that loss of Nxt1 leads to reduced transcription of tMAC targets. A reporter transcript from a tMAC-dependent promoter is under-expressed in Nxt1 mutants, however the same transcript accumulates in mutants if driven by a tMAC-independent promoter. Thus, in Drosophila primary spermatocytes, the transcription factor used to activate expression of a transcript, rather than the RNA sequence itself or the core transcription machinery, determines whether this expression requires Nxt1. We additionally find that transcripts from intron-less genes are more sensitive to loss of Nxt1 function than those from intron-containing genes and propose a mechanism in which transcript processing feeds back to increase activity of a tissue specific transcription complex." @default.
• W2149463911 created "2016-06-24" @default.
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• W2149463911 date "2013-06-06" @default.
• W2149463911 modified "2023-10-12" @default.
• W2149463911 title "The RNA Export Factor, Nxt1, Is Required for Tissue Specific Transcriptional Regulation" @default.
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• W2149463911 doi "https://doi.org/10.1371/journal.pgen.1003526" @default.
• W2149463911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3674997" @default.
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• W2149463911 hasPublicationYear "2013" @default.
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