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- W2149464998 abstract "Apolipoprotein E (ApoE) is an abundant plasma protein that interacts with low density lipoprotein receptors and other proteins, participating in the transport of cholesterol and lipids. Research has revealed many other roles for this multifunctional protein. ApoE is polymorphic and exists in three major isoforms: ApoE2, ApoE3 (the most common isoform) and ApoE4, which differ by only one amino acid, at positions 112 and 158. The altered binding to lipids and receptors by ApoE isoforms E2 and E4 results in an elevated risk for neurological, cerebrovascular and cardiovascular pathologies. Most notably, ApoE4 is associated with an elevated risk (relative to E3) for Alzheimer's disease. The application of mass spectrometry for genotyping and also direct measurement of ApoE protein isoforms is a recent development and is well suited to high-throughput applications. The precise quantification of protein isoforms will allow better characterization of effects resulting from heterozygous APOE genotypes." @default.
- W2149464998 created "2016-06-24" @default.
- W2149464998 creator A5020104307 @default.
- W2149464998 creator A5034622744 @default.
- W2149464998 creator A5055280739 @default.
- W2149464998 date "2014-04-22" @default.
- W2149464998 modified "2023-10-16" @default.
- W2149464998 title "The role of apolipoprotein E in neurodegeneration and cardiovascular disease" @default.
- W2149464998 cites W148236777 @default.
- W2149464998 cites W1487675939 @default.
- W2149464998 cites W1502314515 @default.
- W2149464998 cites W1555846320 @default.
- W2149464998 cites W1577502861 @default.
- W2149464998 cites W1604834291 @default.
- W2149464998 cites W1838193685 @default.
- W2149464998 cites W1965780119 @default.
- W2149464998 cites W1966876863 @default.
- W2149464998 cites W1974439414 @default.
- W2149464998 cites W1974638111 @default.
- W2149464998 cites W1980309511 @default.
- W2149464998 cites W1982231999 @default.
- W2149464998 cites W1984139645 @default.
- W2149464998 cites W1984525664 @default.
- W2149464998 cites W1984737558 @default.
- W2149464998 cites W1985137206 @default.
- W2149464998 cites W1988350864 @default.
- W2149464998 cites W1989376534 @default.
- W2149464998 cites W1990016625 @default.
- W2149464998 cites W1990078328 @default.
- W2149464998 cites W1992681087 @default.
- W2149464998 cites W1994259160 @default.
- W2149464998 cites W1999300900 @default.
- W2149464998 cites W1999530134 @default.
- W2149464998 cites W2000913322 @default.
- W2149464998 cites W2004960515 @default.
- W2149464998 cites W2006599070 @default.
- W2149464998 cites W2007249961 @default.
- W2149464998 cites W2012676773 @default.
- W2149464998 cites W2013075704 @default.
- W2149464998 cites W2014472596 @default.
- W2149464998 cites W2020737544 @default.
- W2149464998 cites W2021181758 @default.
- W2149464998 cites W2029380839 @default.
- W2149464998 cites W2030272691 @default.
- W2149464998 cites W2031644654 @default.
- W2149464998 cites W2034968148 @default.
- W2149464998 cites W2035888786 @default.
- W2149464998 cites W2036362108 @default.
- W2149464998 cites W2044755530 @default.
- W2149464998 cites W2057545775 @default.
- W2149464998 cites W2058116753 @default.
- W2149464998 cites W2059184753 @default.
- W2149464998 cites W2061530946 @default.
- W2149464998 cites W2066644955 @default.
- W2149464998 cites W2076453964 @default.
- W2149464998 cites W2079090326 @default.
- W2149464998 cites W2080831516 @default.
- W2149464998 cites W2081337065 @default.
- W2149464998 cites W2084687969 @default.
- W2149464998 cites W2085686969 @default.
- W2149464998 cites W2086881464 @default.
- W2149464998 cites W2088424318 @default.
- W2149464998 cites W2091212732 @default.
- W2149464998 cites W2094294016 @default.
- W2149464998 cites W2096590285 @default.
- W2149464998 cites W2098247882 @default.
- W2149464998 cites W2100216005 @default.
- W2149464998 cites W2100918387 @default.
- W2149464998 cites W2102736631 @default.
- W2149464998 cites W2105102381 @default.
- W2149464998 cites W2106118564 @default.
- W2149464998 cites W2111774300 @default.
- W2149464998 cites W2113711307 @default.
- W2149464998 cites W2123098521 @default.
- W2149464998 cites W2125418295 @default.
- W2149464998 cites W2126423643 @default.
- W2149464998 cites W2129029307 @default.
- W2149464998 cites W2131034421 @default.
- W2149464998 cites W2135148614 @default.
- W2149464998 cites W2139818289 @default.
- W2149464998 cites W2149562628 @default.
- W2149464998 cites W2150541142 @default.
- W2149464998 cites W2151655754 @default.
- W2149464998 cites W2154838738 @default.
- W2149464998 cites W2155270826 @default.
- W2149464998 cites W2163842072 @default.
- W2149464998 cites W2166593844 @default.
- W2149464998 cites W2169484904 @default.
- W2149464998 cites W2171915544 @default.
- W2149464998 cites W2338858604 @default.
- W2149464998 cites W255871888 @default.
- W2149464998 doi "https://doi.org/10.1586/14789450.2014.901892" @default.
- W2149464998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24754513" @default.
- W2149464998 hasPublicationYear "2014" @default.
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