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• W2149476799 abstract "Irreversible electroporation (IRE) uses high-voltage pulses applied to tissue, which cause dielectric breakdown of cell membranes resulting in cell death. IRE is a promising technique for ablation of nonresectable tumors because it can be configured to spare critical structures such as blood vessels. A consequence of pulse application is an increase in tissue electrical conductivity due to current pathways being opened in cell membranes. We propose a novel IRE method introducing electrode switching and pulse sequencing in which tissue conductivity is first increased using preparatory pulses in order to form high-conductivity zones, which then helps provide higher electric field intensity within the targeted tissue as subsequent pulses are applied, and hence, enhances the efficiency and selectivity of the IRE treatment. We demonstrate the potential of this method using computational models on simple geometries." @default.
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• W2149476799 date "2012-03-01" @default.
• W2149476799 modified "2023-09-26" @default.
• W2149476799 title "Electrode Activation Sequencing Employing Conductivity Changes in Irreversible Electroporation Tissue Ablation" @default.
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• W2149476799 doi "https://doi.org/10.1109/tbme.2011.2180722" @default.
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