FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149477038> ?p ?o ?g. }

• W2149477038 endingPage "276" @default.
• W2149477038 startingPage "265" @default.
• W2149477038 abstract "Abstract Coffee drinking has been associated with reduced incidence of colorectal cancer, possibly via chemoprotection/modification of the metabolism of dietary heterocyclic amine carcinogens such as 2‐amino‐1‐methyl‐6‐phenylimidazo‐[4,5‐b]pyridine (PhIP) by kahweol and cafestol palmitates (K/C), two components of unfiltered coffee. Using the PhIP‐exposed male Fisher F344 rat as a model, K/C have been shown to reduce colonic PhIP‐DNA adducts by > 50%. We have used the male F344 rat to investigate the effects of dietary K/C (0.02–0.2% as a 1:1 mixture) on the metabolism of PhIP by N ‐acetyltransferase‐ (NAT), sulfotransferase‐ (SULT), and glutathione‐dependent pathways. K/C decreased hepatic NAT‐dependent PhIP activation by up to 80% in a dose‐dependent manner. Conversely, hepatic glutathione S ‐transferase (GST) activity/expression increased, e.g., 3–4 fold toward 1‐chloro‐2,4‐dinitrobenzene (total activity), up to 23‐fold toward 4‐vinylpyridine (rGSTP1), and ∼ 7‐fold for rGSTA2 protein. These effects had fully developed after 5 days of the test diet and persisted for at least 5 days after withdrawal of K/C. Hepatic glutathione increased two‐ to threefold and this increase was more short‐lived than other changes. K/C did not modify hepatic SULT activity or colon NAT and GST activities. Benzylisothiocyanate and black tea, which have also been shown to reduce the formation of PhIP‐DNA adducts in this model, had little effect on hepatic NAT, SULT, GST, or GSH. In primary culture of rat hepatocytes, both kahweol and cafestol palmitates reduced NAT activity by 80%. In summary, the unique potential of K/C to convert rapid acetylators to a slow acetylator phenotype, accompanied by GST induction, might contribute to chemoprevention against cancers associated with heterocyclic amines. Environ. Mol. Mutagen. 44:265–276, 2004. © 2004 Wiley‐Liss, Inc." @default.
• W2149477038 created "2016-06-24" @default.
• W2149477038 creator A5006561542 @default.
• W2149477038 creator A5012217277 @default.
• W2149477038 creator A5048047213 @default.
• W2149477038 creator A5051576299 @default.
• W2149477038 creator A5055083521 @default.
• W2149477038 creator A5055235091 @default.
• W2149477038 creator A5079208384 @default.
• W2149477038 creator A5087771359 @default.
• W2149477038 creator A5087773135 @default.
• W2149477038 creator A5089970764 @default.
• W2149477038 creator A5090947366 @default.
• W2149477038 date "2004-01-01" @default.
• W2149477038 modified "2023-10-14" @default.
• W2149477038 title "Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepaticN-acetyltransferase and glutathioneS-transferase activities" @default.
• W2149477038 cites W117744880 @default.
• W2149477038 cites W1488095479 @default.
• W2149477038 cites W1527243195 @default.
• W2149477038 cites W1536916609 @default.
• W2149477038 cites W1548783251 @default.
• W2149477038 cites W1558053197 @default.
• W2149477038 cites W1562826829 @default.
• W2149477038 cites W1581414347 @default.
• W2149477038 cites W1968335729 @default.
• W2149477038 cites W1978976783 @default.
• W2149477038 cites W1984221310 @default.
• W2149477038 cites W1986009138 @default.
• W2149477038 cites W1986732731 @default.
• W2149477038 cites W1990006342 @default.
• W2149477038 cites W1994615356 @default.
• W2149477038 cites W1995412453 @default.
• W2149477038 cites W2004618611 @default.
• W2149477038 cites W2005855197 @default.
• W2149477038 cites W2005941511 @default.
• W2149477038 cites W2007805496 @default.
• W2149477038 cites W2011833082 @default.
• W2149477038 cites W2012062618 @default.
• W2149477038 cites W2012422153 @default.
• W2149477038 cites W2013010647 @default.
• W2149477038 cites W2014352349 @default.
• W2149477038 cites W2031528658 @default.
• W2149477038 cites W2041816161 @default.
• W2149477038 cites W2043836811 @default.
• W2149477038 cites W2044107958 @default.
• W2149477038 cites W2046750894 @default.
• W2149477038 cites W2046931075 @default.
• W2149477038 cites W2049474439 @default.
• W2149477038 cites W2051611282 @default.
• W2149477038 cites W2052087204 @default.
• W2149477038 cites W2052608521 @default.
• W2149477038 cites W2055433723 @default.
• W2149477038 cites W2055995053 @default.
• W2149477038 cites W2057797408 @default.
• W2149477038 cites W2060526949 @default.
• W2149477038 cites W2062149423 @default.
• W2149477038 cites W2070451131 @default.
• W2149477038 cites W2072938445 @default.
• W2149477038 cites W2074512495 @default.
• W2149477038 cites W2074963199 @default.
• W2149477038 cites W2075264224 @default.
• W2149477038 cites W2077931051 @default.
• W2149477038 cites W2083161231 @default.
• W2149477038 cites W2084314401 @default.
• W2149477038 cites W2084760140 @default.
• W2149477038 cites W2086329259 @default.
• W2149477038 cites W2088536713 @default.
• W2149477038 cites W2090341656 @default.
• W2149477038 cites W2094019696 @default.
• W2149477038 cites W2094335647 @default.
• W2149477038 cites W2099008485 @default.
• W2149477038 cites W2106983211 @default.
• W2149477038 cites W2117894833 @default.
• W2149477038 cites W2121856284 @default.
• W2149477038 cites W2123528142 @default.
• W2149477038 cites W2126921546 @default.
• W2149477038 cites W2127321206 @default.
• W2149477038 cites W2140815494 @default.
• W2149477038 cites W2153235080 @default.
• W2149477038 cites W2163206150 @default.
• W2149477038 cites W2171438080 @default.
• W2149477038 cites W2280568339 @default.
• W2149477038 cites W4293247451 @default.
• W2149477038 doi "https://doi.org/10.1002/em.20052" @default.
• W2149477038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15468054" @default.
• W2149477038 hasPublicationYear "2004" @default.
• W2149477038 type Work @default.
• W2149477038 sameAs 2149477038 @default.
• W2149477038 citedByCount "52" @default.
• W2149477038 countsByYear W21494770382012 @default.
• W2149477038 countsByYear W21494770382013 @default.
• W2149477038 countsByYear W21494770382014 @default.
• W2149477038 countsByYear W21494770382015 @default.
• W2149477038 countsByYear W21494770382016 @default.
• W2149477038 countsByYear W21494770382017 @default.
• W2149477038 countsByYear W21494770382018 @default.
• W2149477038 countsByYear W21494770382019 @default.
• W2149477038 countsByYear W21494770382022 @default.

• next