FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149477890> ?p ?o ?g. }

• W2149477890 abstract "In budding yeast, a highly conserved heterodimeric protein complex that is composed of the Rpb4 and Rpb7 proteins within RNA polymerase II shuttles between the nucleus and cytoplasm where it coordinates various steps of gene expression by associating with mRNAs. Although distinct stages of gene expression potentially contribute to the regulation of cellular lifespan, little is known about the underlying mechanisms. Here, we addressed the role of the dissociable Rpb4/7 heterodimeric protein complex in the regulation of replicative lifespan during various stages of gene expression in the yeast Saccharomyces cerevisiae. We observed that the loss of Rpb4 resulted in a shortened lifespan. In contrast, we found that defects in the dissociation of Rpb4/7 from the RNA polymerase core complex and in translation initiation steps affected by Rpb4/7 did not impact lifespan. Tandem affinity purification experiments demonstrated that Rpb7 physically associates with Tpk2 and Pat1, which are both implicated in mRNA degradation. Consistent with this data, the loss of the mRNA decay regulators Pat1 and Dhh1 reduced the cellular lifespan. In summary, our findings further reinforce the pivotal role of Rpb4/7 in the coordination of distinct steps of gene expression and suggest that among the many stages of gene expression, mRNA decay is a critical process that is required for normal replicative lifespan." @default.
• W2149477890 created "2016-06-24" @default.
• W2149477890 creator A5032440549 @default.
• W2149477890 creator A5067136962 @default.
• W2149477890 creator A5077533501 @default.
• W2149477890 creator A5079868589 @default.
• W2149477890 date "2013-11-01" @default.
• W2149477890 modified "2023-09-24" @default.
• W2149477890 title "The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process" @default.
• W2149477890 cites W1492873553 @default.
• W2149477890 cites W1502461682 @default.
• W2149477890 cites W1522516056 @default.
• W2149477890 cites W1575542444 @default.
• W2149477890 cites W1911817655 @default.
• W2149477890 cites W1965343063 @default.
• W2149477890 cites W1966036297 @default.
• W2149477890 cites W1966695149 @default.
• W2149477890 cites W1967938775 @default.
• W2149477890 cites W1990955843 @default.
• W2149477890 cites W1992663222 @default.
• W2149477890 cites W1997123719 @default.
• W2149477890 cites W1999204155 @default.
• W2149477890 cites W2003911773 @default.
• W2149477890 cites W2007683530 @default.
• W2149477890 cites W2007943229 @default.
• W2149477890 cites W2011368229 @default.
• W2149477890 cites W2013005251 @default.
• W2149477890 cites W2013281906 @default.
• W2149477890 cites W2017117976 @default.
• W2149477890 cites W2028735905 @default.
• W2149477890 cites W2037313242 @default.
• W2149477890 cites W2046195682 @default.
• W2149477890 cites W2062449777 @default.
• W2149477890 cites W2085309970 @default.
• W2149477890 cites W2085574038 @default.
• W2149477890 cites W2087299162 @default.
• W2149477890 cites W2102863668 @default.
• W2149477890 cites W2107402875 @default.
• W2149477890 cites W2121584386 @default.
• W2149477890 cites W2123847993 @default.
• W2149477890 cites W2134530067 @default.
• W2149477890 cites W2135969650 @default.
• W2149477890 cites W2141325721 @default.
• W2149477890 cites W2141879963 @default.
• W2149477890 cites W2145054653 @default.
• W2149477890 cites W2146968192 @default.
• W2149477890 cites W2149026495 @default.
• W2149477890 cites W2152927202 @default.
• W2149477890 cites W2158059089 @default.
• W2149477890 cites W2158534339 @default.
• W2149477890 cites W2160718564 @default.
• W2149477890 doi "https://doi.org/10.1016/j.bbrc.2013.10.079" @default.
• W2149477890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24513203" @default.
• W2149477890 hasPublicationYear "2013" @default.
• W2149477890 type Work @default.
• W2149477890 sameAs 2149477890 @default.
• W2149477890 citedByCount "6" @default.
• W2149477890 countsByYear W21494778902014 @default.
• W2149477890 countsByYear W21494778902015 @default.
• W2149477890 countsByYear W21494778902018 @default.
• W2149477890 countsByYear W21494778902019 @default.
• W2149477890 crossrefType "journal-article" @default.
• W2149477890 hasAuthorship W2149477890A5032440549 @default.
• W2149477890 hasAuthorship W2149477890A5067136962 @default.
• W2149477890 hasAuthorship W2149477890A5077533501 @default.
• W2149477890 hasAuthorship W2149477890A5079868589 @default.
• W2149477890 hasConcept C101762097 @default.
• W2149477890 hasConcept C104317684 @default.
• W2149477890 hasConcept C105580179 @default.
• W2149477890 hasConcept C150194340 @default.
• W2149477890 hasConcept C153911025 @default.
• W2149477890 hasConcept C165864922 @default.
• W2149477890 hasConcept C41282012 @default.
• W2149477890 hasConcept C54355233 @default.
• W2149477890 hasConcept C64350747 @default.
• W2149477890 hasConcept C67705224 @default.
• W2149477890 hasConcept C86803240 @default.
• W2149477890 hasConcept C95444343 @default.
• W2149477890 hasConceptScore W2149477890C101762097 @default.
• W2149477890 hasConceptScore W2149477890C104317684 @default.
• W2149477890 hasConceptScore W2149477890C105580179 @default.
• W2149477890 hasConceptScore W2149477890C150194340 @default.
• W2149477890 hasConceptScore W2149477890C153911025 @default.
• W2149477890 hasConceptScore W2149477890C165864922 @default.
• W2149477890 hasConceptScore W2149477890C41282012 @default.
• W2149477890 hasConceptScore W2149477890C54355233 @default.
• W2149477890 hasConceptScore W2149477890C64350747 @default.
• W2149477890 hasConceptScore W2149477890C67705224 @default.
• W2149477890 hasConceptScore W2149477890C86803240 @default.
• W2149477890 hasConceptScore W2149477890C95444343 @default.
• W2149477890 hasFunder F4320322120 @default.
• W2149477890 hasLocation W21494778901 @default.
• W2149477890 hasLocation W21494778902 @default.
• W2149477890 hasOpenAccess W2149477890 @default.
• W2149477890 hasPrimaryLocation W21494778901 @default.
• W2149477890 hasRelatedWork W1505729043 @default.
• W2149477890 hasRelatedWork W167874984 @default.
• W2149477890 hasRelatedWork W19715912 @default.
• W2149477890 hasRelatedWork W1979593676 @default.
• W2149477890 hasRelatedWork W1981662335 @default.

• next