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• W2149479040 abstract "Sarcolemma Ca2+ influx, necessary for store refilling, was well maintained, over a wide range (-70 to + 40 mV) of membrane voltages, in guinea-pig single circular colonic smooth muscle cells, as indicated by the magnitude of InsP3-evoked Ca2+ transients. This apparent voltage independence of store refilling was achieved by the activity of sarcolemma Ca2+ channels some of which were voltage gated while others were not. At negative membrane potentials (e.g. -70 mV), Ca2+ influx through channels which lacked voltage gating provided for store refilling while at positive membrane potentials (e.g. +40 mV) voltage-gated Ca2+ channels were largely responsible. Sarcolemma voltage-gated Ca2+ currents were not activated following store depletion. Removal of external Ca2+ or the addition of the Ca2+ channel blocker nimodipine (1 microM) inhibited store refilling, as assessed by the magnitude of InsP3-evoked Ca2+ transients, with little or no change in bulk average cytoplasmic Ca2+ concentration. One hypothesis for these results is that the store may refill from a high subsarcolemma Ca2+ gradient. Influx via channels, some of which are voltage gated and others which lack voltage gating, may permit the establishment of a subsarcolemma Ca2+ gradient. Store access to the gradient allows InsP3-evoked Ca2+ signalling to be maintained over a wide voltage range in colonic smooth muscle." @default.
• W2149479040 created "2016-06-24" @default.
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• W2149479040 date "2000-05-01" @default.
• W2149479040 modified "2023-09-26" @default.
• W2149479040 title "Two Ca²⁺ entry pathways mediate Ins<i>P</i>₃‐sensitive store refilling in guinea‐pig colonic smooth muscle" @default.
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• W2149479040 doi "https://doi.org/10.1111/j.1469-7793.2000.00113.x" @default.
• W2149479040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269931" @default.
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