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• W2149479217 abstract "<h3>Background</h3> Obesity is a complex trait with both environmental and genetic contributors. Genome-wide association studies have identified several variants that are robustly associated with obesity and body mass index (BMI), many of which are found within genes involved in appetite regulation. Currently, genetic association data for obesity are lacking in Africans—a single genome-wide association study and a few replication studies have been published in West Africa, but none have been performed in a South African population. <h3>Objective</h3> To assess the association of candidate loci with BMI in black South Africans. The authors focused on single nucleotide polymorphisms (SNPs) in the <i>FTO</i>, <i>LEP</i>, <i>LEPR</i>, <i>MC4R</i>, <i>NPY2R</i> and <i>POMC</i> genes. <h3>Design</h3> A genetic association study. <h3>Participants</h3> 990 randomly selected individuals from the larger Birth to Twenty cohort (a longitudinal birth cohort study of health and development in Africans). <h3>Measures</h3> The authors genotyped 44 SNPs within the six candidate genes that included known BMI-associated SNPs and tagSNPs based on linkage disequilibrium in an African population for <i>FTO</i>, <i>LEP</i> and <i>NPY2R</i>. To assess population substructure, the authors included 18 ancestry informative markers. Weight, height, sex, sex-specific pubertal stage and exact age collected during adolescence (13 years) were used to identify loci that predispose to obesity early in life. <h3>Results</h3> Sex, sex-specific pubertal stage and exact age together explain 14.3% of the variation in log(BMI) at age 13. After adjustment for these factors, four SNPs were individually significantly associated with BMI: <i>FTO</i> rs17817449 (p=0.022), <i>LEP</i> rs10954174 (p=0.0004), <i>LEP</i> rs6966536 (p=0.012) and <i>MC4R</i> rs17782313 (p=0.045). Together the four SNPs account for 2.1% of the variation in log(BMI). Each risk allele was associated with an estimated average increase of 2.5% in BMI. <h3>Conclusions</h3> The study highlighted SNPs in <i>FTO</i> and <i>MC4R</i> as potential genetic markers of obesity risk in South Africans. The association with two SNPs in the 3′ untranslated region of the <i>LEP</i> gene is novel." @default.
• W2149479217 created "2016-06-24" @default.
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• W2149479217 date "2012-01-01" @default.
• W2149479217 modified "2023-10-18" @default.
• W2149479217 title "Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study" @default.
• W2149479217 cites W1512875938 @default.
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• W2149479217 cites W1965262794 @default.
• W2149479217 cites W1971771110 @default.
• W2149479217 cites W1975365642 @default.
• W2149479217 cites W1975621328 @default.
• W2149479217 cites W1987830443 @default.
• W2149479217 cites W1991317114 @default.
• W2149479217 cites W2000347915 @default.
• W2149479217 cites W2006171501 @default.
• W2149479217 cites W2026855071 @default.
• W2149479217 cites W2027934956 @default.
• W2149479217 cites W2028335133 @default.
• W2149479217 cites W2029471699 @default.
• W2149479217 cites W2035126508 @default.
• W2149479217 cites W2043154679 @default.
• W2149479217 cites W2051864455 @default.
• W2149479217 cites W2061712427 @default.
• W2149479217 cites W2062886649 @default.
• W2149479217 cites W2065053963 @default.
• W2149479217 cites W2076011171 @default.
• W2149479217 cites W2082947145 @default.
• W2149479217 cites W2086678897 @default.
• W2149479217 cites W2087941642 @default.
• W2149479217 cites W2089352857 @default.
• W2149479217 cites W2090290755 @default.
• W2149479217 cites W2092165051 @default.
• W2149479217 cites W2093011816 @default.
• W2149479217 cites W2093513672 @default.
• W2149479217 cites W2098126593 @default.
• W2149479217 cites W2098161436 @default.
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• W2149479217 cites W2129316818 @default.
• W2149479217 cites W2129608374 @default.
• W2149479217 cites W2130957039 @default.
• W2149479217 cites W2138073275 @default.
• W2149479217 cites W2140026462 @default.
• W2149479217 cites W2145707775 @default.
• W2149479217 cites W2146439626 @default.
• W2149479217 cites W2147311167 @default.
• W2149479217 cites W2148732309 @default.
• W2149479217 cites W2151291137 @default.
• W2149479217 cites W2152664025 @default.
• W2149479217 cites W2155635136 @default.
• W2149479217 cites W2158370471 @default.
• W2149479217 cites W2159292729 @default.
• W2149479217 cites W2162530578 @default.
• W2149479217 cites W2162854231 @default.
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• W2149479217 cites W2165017806 @default.
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• W2149479217 cites W2238147730 @default.
• W2149479217 cites W2334252978 @default.
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• W2149479217 doi "https://doi.org/10.1136/bmjopen-2012-000873" @default.
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