FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149485740> ?p ?o ?g. }

• W2149485740 endingPage "454" @default.
• W2149485740 startingPage "443" @default.
• W2149485740 abstract "The number of human kidney transplants has increased rapidly in recent years, but the need greatly exceeds organ availability. Induction of appropriate kidney differentiation and growth from stem or progenitor cell populations represents an attractive option to combat chronic kidney donor shortage. In an analogy to haematopoietic stem cells, which are much more efficient in giving rise to blood than to other cell types, if any at all, renal stem cells could afford an unlimited source for regenerating nephrons. While a single nephrogenic stem cell has not been characterised, indirect evidence suggests that a renal stem cell population is contained within the metanephric mesenchyme, which along with a branch of the Wolffian duct represents the direct precursor of the mature kidney. Human tissue fragments derived from these developing precursors can regenerate renal structures when grafted into mice. Moreover, recent data pinpoints a window of time in human and pig kidney development that may be optimal for transplantation into mature recipients. 'Window' transplants are defined by their remarkable ability to grow, differentiate and undergo vascularisation, achieving successful organogenesis of urine-producing miniature kidneys with no evidence of transdifferentiation into non-renal cell types, lack of tumourigenicity and reduced immunogenicity compared with adult counterparts. In contrast, 'non-window' transplants (earlier or later in gestation) can form teratomas or are more prone to immune rejection and are less suitable for organogenesis. Hopefully, the use of stage-specific early human and porcine kidney precursors to cultivate mature kidney cells in vivo, possibly in conjunction with other modalities of stem cell technology and tissue engineering, will prove valuable to sustain life in patients with failing kidneys." @default.
• W2149485740 created "2016-06-24" @default.
• W2149485740 creator A5050824632 @default.
• W2149485740 creator A5068965669 @default.
• W2149485740 date "2004-04-01" @default.
• W2149485740 modified "2023-09-23" @default.
• W2149485740 title "Embryonic committed stem cells as a solution to kidney donor shortage" @default.
• W2149485740 cites W1514371770 @default.
• W2149485740 cites W1542326554 @default.
• W2149485740 cites W1557258230 @default.
• W2149485740 cites W1585899767 @default.
• W2149485740 cites W1601908524 @default.
• W2149485740 cites W1611935467 @default.
• W2149485740 cites W1621991227 @default.
• W2149485740 cites W1950995033 @default.
• W2149485740 cites W1966539578 @default.
• W2149485740 cites W1970023965 @default.
• W2149485740 cites W1974359211 @default.
• W2149485740 cites W1974862051 @default.
• W2149485740 cites W1976221714 @default.
• W2149485740 cites W1982524610 @default.
• W2149485740 cites W1991374176 @default.
• W2149485740 cites W1991560559 @default.
• W2149485740 cites W2000849265 @default.
• W2149485740 cites W2006499389 @default.
• W2149485740 cites W2007511178 @default.
• W2149485740 cites W2008882737 @default.
• W2149485740 cites W2012631683 @default.
• W2149485740 cites W2016823790 @default.
• W2149485740 cites W2019304588 @default.
• W2149485740 cites W2028264823 @default.
• W2149485740 cites W2030002999 @default.
• W2149485740 cites W2030916798 @default.
• W2149485740 cites W2031534226 @default.
• W2149485740 cites W2032167439 @default.
• W2149485740 cites W2032979838 @default.
• W2149485740 cites W2033168775 @default.
• W2149485740 cites W2033284482 @default.
• W2149485740 cites W2034951155 @default.
• W2149485740 cites W2039431980 @default.
• W2149485740 cites W2041143782 @default.
• W2149485740 cites W2045817678 @default.
• W2149485740 cites W2048258494 @default.
• W2149485740 cites W2048746176 @default.
• W2149485740 cites W2048794853 @default.
• W2149485740 cites W2048833550 @default.
• W2149485740 cites W2053685914 @default.
• W2149485740 cites W2054568222 @default.
• W2149485740 cites W2058754454 @default.
• W2149485740 cites W2060146566 @default.
• W2149485740 cites W2075037940 @default.
• W2149485740 cites W2077427425 @default.
• W2149485740 cites W2078538267 @default.
• W2149485740 cites W2089154676 @default.
• W2149485740 cites W2094283653 @default.
• W2149485740 cites W2097577343 @default.
• W2149485740 cites W2103054294 @default.
• W2149485740 cites W2112620963 @default.
• W2149485740 cites W2113669746 @default.
• W2149485740 cites W2114307150 @default.
• W2149485740 cites W2128256270 @default.
• W2149485740 cites W2129852286 @default.
• W2149485740 cites W2133501984 @default.
• W2149485740 cites W2140979322 @default.
• W2149485740 cites W2142472665 @default.
• W2149485740 cites W2145558392 @default.
• W2149485740 cites W2153234211 @default.
• W2149485740 cites W2163233392 @default.
• W2149485740 cites W2169884542 @default.
• W2149485740 cites W2269657865 @default.
• W2149485740 cites W2415054673 @default.
• W2149485740 cites W4232574208 @default.
• W2149485740 doi "https://doi.org/10.1517/14712598.4.4.443" @default.
• W2149485740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15102595" @default.
• W2149485740 hasPublicationYear "2004" @default.
• W2149485740 type Work @default.
• W2149485740 sameAs 2149485740 @default.
• W2149485740 citedByCount "17" @default.
• W2149485740 countsByYear W21494857402012 @default.
• W2149485740 countsByYear W21494857402015 @default.
• W2149485740 crossrefType "journal-article" @default.
• W2149485740 hasAuthorship W2149485740A5050824632 @default.
• W2149485740 hasAuthorship W2149485740A5068965669 @default.
• W2149485740 hasConcept C104317684 @default.
• W2149485740 hasConcept C126322002 @default.
• W2149485740 hasConcept C130010870 @default.
• W2149485740 hasConcept C134018914 @default.
• W2149485740 hasConcept C138798377 @default.
• W2149485740 hasConcept C145103041 @default.
• W2149485740 hasConcept C198826908 @default.
• W2149485740 hasConcept C201750760 @default.
• W2149485740 hasConcept C203014093 @default.
• W2149485740 hasConcept C20875687 @default.
• W2149485740 hasConcept C2776340970 @default.
• W2149485740 hasConcept C2777632694 @default.
• W2149485740 hasConcept C2780091579 @default.
• W2149485740 hasConcept C28328180 @default.
• W2149485740 hasConcept C2908647359 @default.

• next