FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149492052> ?p ?o ?g. }

• W2149492052 endingPage "320" @default.
• W2149492052 startingPage "314" @default.
• W2149492052 abstract "The evolution of indolent lymphomas to aggressive histologies, known as histologic transformation (HT), is a frequent occurrence for all subtypes of low grade B cell lymphoproliferative disorders. The risk of developing HT is approximately 3% per year for patients with indolent lymphoma. Clinically these present with a rapid change in the behavior of the disease, with evidence of a highly proliferative malignancy with a propensity to involve extranodal sites. The prognosis of patients following transformation is generally poor, with median survival of about 12 months. Recent studies suggest that the development of HT is very complex with the acquisition of multiple cytogenetic abnormalities in the low-grade lymphoma cells prior to HT. To date, there are no biologic or genetic parameters predictive of the development of HT. A myriad of genetic lesions have been identified in HT, and provide insight into its pathogenesis. These include genes regulating proliferation (C-MYC and C-MYC-regulated genes); control of the cell cycle (CDKN2a and CDKN2B); and programmed cell death (TP53, C-MYC, and BCL2). Gene expression profiling has been applied to the study of HT and has increased our understanding of the transformation process. There has been limited progress in the treatment of patients with HT. Conventional chemotherapy is generally of limited benefit, although a subset of patients are long-term survivors following high-dose therapy and autologous stem cell transplantation. The use of radioimmunotherapy and new agents targeting specific lesions or aberrant pathways may impact on the management of these aggressive diseases." @default.
• W2149492052 created "2016-06-24" @default.
• W2149492052 creator A5037942629 @default.
• W2149492052 date "2005-01-01" @default.
• W2149492052 modified "2023-09-25" @default.
• W2149492052 title "Biology and Management of Histologic Transformation of Indolent Lymphoma" @default.
• W2149492052 cites W1518837415 @default.
• W2149492052 cites W1565408903 @default.
• W2149492052 cites W1777323899 @default.
• W2149492052 cites W1897819006 @default.
• W2149492052 cites W1969267175 @default.
• W2149492052 cites W1977903128 @default.
• W2149492052 cites W1982706034 @default.
• W2149492052 cites W1994969140 @default.
• W2149492052 cites W1995409143 @default.
• W2149492052 cites W2019795158 @default.
• W2149492052 cites W2030071549 @default.
• W2149492052 cites W2040990336 @default.
• W2149492052 cites W2047750426 @default.
• W2149492052 cites W2052825705 @default.
• W2149492052 cites W2054151493 @default.
• W2149492052 cites W2055643760 @default.
• W2149492052 cites W2065791513 @default.
• W2149492052 cites W2075053994 @default.
• W2149492052 cites W2079162000 @default.
• W2149492052 cites W2081222723 @default.
• W2149492052 cites W2086135001 @default.
• W2149492052 cites W2090692723 @default.
• W2149492052 cites W2096242966 @default.
• W2149492052 cites W2099249352 @default.
• W2149492052 cites W2103929387 @default.
• W2149492052 cites W2104897136 @default.
• W2149492052 cites W2106461522 @default.
• W2149492052 cites W2110646221 @default.
• W2149492052 cites W2119691395 @default.
• W2149492052 cites W2125147131 @default.
• W2149492052 cites W2132598458 @default.
• W2149492052 cites W2139051540 @default.
• W2149492052 cites W2141498296 @default.
• W2149492052 cites W2150074331 @default.
• W2149492052 cites W2152911354 @default.
• W2149492052 cites W2157732665 @default.
• W2149492052 cites W2164606502 @default.
• W2149492052 cites W2165117825 @default.
• W2149492052 cites W2172208779 @default.
• W2149492052 cites W2172296235 @default.
• W2149492052 cites W2239810334 @default.
• W2149492052 cites W2244093888 @default.
• W2149492052 cites W2248054795 @default.
• W2149492052 cites W2259826284 @default.
• W2149492052 cites W2314416506 @default.
• W2149492052 cites W2557206785 @default.
• W2149492052 doi "https://doi.org/10.1182/asheducation-2005.1.314" @default.
• W2149492052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16304397" @default.
• W2149492052 hasPublicationYear "2005" @default.
• W2149492052 type Work @default.
• W2149492052 sameAs 2149492052 @default.
• W2149492052 citedByCount "32" @default.
• W2149492052 countsByYear W21494920522012 @default.
• W2149492052 countsByYear W21494920522013 @default.
• W2149492052 countsByYear W21494920522014 @default.
• W2149492052 countsByYear W21494920522015 @default.
• W2149492052 countsByYear W21494920522016 @default.
• W2149492052 countsByYear W21494920522017 @default.
• W2149492052 countsByYear W21494920522018 @default.
• W2149492052 countsByYear W21494920522019 @default.
• W2149492052 countsByYear W21494920522021 @default.
• W2149492052 countsByYear W21494920522022 @default.
• W2149492052 crossrefType "journal-article" @default.
• W2149492052 hasAuthorship W2149492052A5037942629 @default.
• W2149492052 hasBestOaLocation W21494920521 @default.
• W2149492052 hasConcept C121608353 @default.
• W2149492052 hasConcept C126322002 @default.
• W2149492052 hasConcept C142724271 @default.
• W2149492052 hasConcept C143998085 @default.
• W2149492052 hasConcept C159654299 @default.
• W2149492052 hasConcept C203014093 @default.
• W2149492052 hasConcept C2776146153 @default.
• W2149492052 hasConcept C2776300330 @default.
• W2149492052 hasConcept C2777058707 @default.
• W2149492052 hasConcept C2777525834 @default.
• W2149492052 hasConcept C2779338263 @default.
• W2149492052 hasConcept C2779399171 @default.
• W2149492052 hasConcept C2780265364 @default.
• W2149492052 hasConcept C2780653079 @default.
• W2149492052 hasConcept C2781214270 @default.
• W2149492052 hasConcept C2911091166 @default.
• W2149492052 hasConcept C502942594 @default.
• W2149492052 hasConcept C542903549 @default.
• W2149492052 hasConcept C71924100 @default.
• W2149492052 hasConcept C86803240 @default.
• W2149492052 hasConceptScore W2149492052C121608353 @default.
• W2149492052 hasConceptScore W2149492052C126322002 @default.
• W2149492052 hasConceptScore W2149492052C142724271 @default.
• W2149492052 hasConceptScore W2149492052C143998085 @default.
• W2149492052 hasConceptScore W2149492052C159654299 @default.
• W2149492052 hasConceptScore W2149492052C203014093 @default.
• W2149492052 hasConceptScore W2149492052C2776146153 @default.

• next