FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149495978> ?p ?o ?g. }

• W2149495978 abstract "Abstract Background A microorganism is able to adapt to changes in its physicochemical or nutritional environment and this is crucial for its survival. The yeast, Saccharomyces cerevisiae , has developed mechanisms to respond to such environmental changes in a rapid and effective manner; such responses may demand a widespread re-programming of gene activity. The dynamics of the re-organization of the cellular activities of S. cerevisiae in response to the sudden and transient removal of either carbon or nitrogen limitation has been studied by following both the short- and long-term changes in yeast's transcriptomic profiles. Results The study, which spans timescales from seconds to hours, has revealed the hierarchy of metabolic and genetic regulatory switches that allow yeast to adapt to, and recover from, a pulse of a previously limiting nutrient. At the transcriptome level, a glucose impulse evoked significant changes in the expression of genes concerned with glycolysis, carboxylic acid metabolism, oxidative phosphorylation, and nucleic acid and sulphur metabolism. In ammonium-limited cultures, an ammonium impulse resulted in the significant changes in the expression of genes involved in nitrogen metabolism and ion transport. Although both perturbations evoked significant changes in the expression of genes involved in the machinery and process of protein synthesis, the transcriptomic response was delayed and less complex in the case of an ammonium impulse. Analysis of the regulatory events by two different system-level, network-based approaches provided further information about dynamic organization of yeast cells as a response to a nutritional change. Conclusions The study provided important information on the temporal organization of transcriptomic organization and underlying regulatory events as a response to both carbon and nitrogen impulse. It has also revealed the importance of a long-term dynamic analysis of the response to the relaxation of a nutritional limitation to understand the molecular basis of the cells' dynamic behaviour." @default.
• W2149495978 created "2016-06-24" @default.
• W2149495978 creator A5024762265 @default.
• W2149495978 creator A5048761291 @default.
• W2149495978 creator A5052840986 @default.
• W2149495978 creator A5069804732 @default.
• W2149495978 creator A5075883279 @default.
• W2149495978 creator A5078597648 @default.
• W2149495978 date "2011-09-25" @default.
• W2149495978 modified "2023-09-26" @default.
• W2149495978 title "How yeast re-programmes its transcriptional profile in response to different nutrient impulses" @default.
• W2149495978 cites W1544923801 @default.
• W2149495978 cites W1644724366 @default.
• W2149495978 cites W1876024155 @default.
• W2149495978 cites W1972780353 @default.
• W2149495978 cites W1975952108 @default.
• W2149495978 cites W1975985109 @default.
• W2149495978 cites W1990987722 @default.
• W2149495978 cites W1993775249 @default.
• W2149495978 cites W2006338742 @default.
• W2149495978 cites W2007418023 @default.
• W2149495978 cites W2009001778 @default.
• W2149495978 cites W2031053624 @default.
• W2149495978 cites W2038437697 @default.
• W2149495978 cites W2045776897 @default.
• W2149495978 cites W2059105292 @default.
• W2149495978 cites W2075622473 @default.
• W2149495978 cites W2080498142 @default.
• W2149495978 cites W2091975733 @default.
• W2149495978 cites W2095236407 @default.
• W2149495978 cites W2097916276 @default.
• W2149495978 cites W2098428745 @default.
• W2149495978 cites W2100771810 @default.
• W2149495978 cites W2101348546 @default.
• W2149495978 cites W2105324766 @default.
• W2149495978 cites W2106671367 @default.
• W2149495978 cites W2107465057 @default.
• W2149495978 cites W2109521384 @default.
• W2149495978 cites W2113378012 @default.
• W2149495978 cites W2120865735 @default.
• W2149495978 cites W2123758431 @default.
• W2149495978 cites W2127754721 @default.
• W2149495978 cites W2132324858 @default.
• W2149495978 cites W2133376865 @default.
• W2149495978 cites W2135187880 @default.
• W2149495978 cites W2136947295 @default.
• W2149495978 cites W2137683543 @default.
• W2149495978 cites W2139947030 @default.
• W2149495978 cites W2144283613 @default.
• W2149495978 cites W2146503498 @default.
• W2149495978 cites W2146573248 @default.
• W2149495978 cites W2149566602 @default.
• W2149495978 cites W2163459094 @default.
• W2149495978 cites W2166898290 @default.
• W2149495978 cites W2169290305 @default.
• W2149495978 cites W2169875902 @default.
• W2149495978 cites W2170164705 @default.
• W2149495978 cites W2171252114 @default.
• W2149495978 doi "https://doi.org/10.1186/1752-0509-5-148" @default.
• W2149495978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3224505" @default.
• W2149495978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21943358" @default.
• W2149495978 hasPublicationYear "2011" @default.
• W2149495978 type Work @default.
• W2149495978 sameAs 2149495978 @default.
• W2149495978 citedByCount "42" @default.
• W2149495978 countsByYear W21494959782012 @default.
• W2149495978 countsByYear W21494959782013 @default.
• W2149495978 countsByYear W21494959782014 @default.
• W2149495978 countsByYear W21494959782015 @default.
• W2149495978 countsByYear W21494959782016 @default.
• W2149495978 countsByYear W21494959782017 @default.
• W2149495978 countsByYear W21494959782018 @default.
• W2149495978 countsByYear W21494959782019 @default.
• W2149495978 countsByYear W21494959782020 @default.
• W2149495978 countsByYear W21494959782021 @default.
• W2149495978 countsByYear W21494959782022 @default.
• W2149495978 crossrefType "journal-article" @default.
• W2149495978 hasAuthorship W2149495978A5024762265 @default.
• W2149495978 hasAuthorship W2149495978A5048761291 @default.
• W2149495978 hasAuthorship W2149495978A5052840986 @default.
• W2149495978 hasAuthorship W2149495978A5069804732 @default.
• W2149495978 hasAuthorship W2149495978A5075883279 @default.
• W2149495978 hasAuthorship W2149495978A5078597648 @default.
• W2149495978 hasBestOaLocation W21494959781 @default.
• W2149495978 hasConcept C104317684 @default.
• W2149495978 hasConcept C125111812 @default.
• W2149495978 hasConcept C150194340 @default.
• W2149495978 hasConcept C162317418 @default.
• W2149495978 hasConcept C2777576037 @default.
• W2149495978 hasConcept C2779222958 @default.
• W2149495978 hasConcept C523546767 @default.
• W2149495978 hasConcept C54355233 @default.
• W2149495978 hasConcept C55493867 @default.
• W2149495978 hasConcept C86803240 @default.
• W2149495978 hasConcept C95444343 @default.
• W2149495978 hasConceptScore W2149495978C104317684 @default.
• W2149495978 hasConceptScore W2149495978C125111812 @default.
• W2149495978 hasConceptScore W2149495978C150194340 @default.
• W2149495978 hasConceptScore W2149495978C162317418 @default.
• W2149495978 hasConceptScore W2149495978C2777576037 @default.

• next