FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149498568> ?p ?o ?g. }

• W2149498568 endingPage "889" @default.
• W2149498568 startingPage "878" @default.
• W2149498568 abstract "Abstract Background Variations within the catechol‐ O ‐methyltransferase ( COMT ) gene have been associated with pain severity in temporomandibular disorders ( TMDs ). Psychological factors such as personal conflicts, life stress and depression, are well known to be associated with onset, severity and chronicity of pain disorders. Aim We hypothesized that the relationship between the COMT gene and TMD pain is modified by depressive symptoms. Methods Cross‐sectional data from the population‐based Study of Health in Pomerania (SHIP) in G ermany were used to estimate additive interactions between depressive symptoms and 22 single‐nucleotide polymorphisms ( SNPs ) of the COMT gene and the neighbouring thioredoxin reductase 2 ( TXNRD2 ) gene on TMD pain. All participants were Caucasian subjects from a rural area in Northeast G ermany. After exclusion of 79 subjects with antidepressant medication, 29.9% of the remaining 3904 subjects reported lifetime depressive symptoms. TMD pain was assessed by a standardized clinical examination. Among various TMD signs, only those that assessed muscle or joint pain on palpation were used as recommended. Results Six SNPs from the first of three COMT / TXNRD2 haploblocks interacted with depressive symptoms on TMD pain (smallest p ‐value: 2.7 × 10 −10 ). In subjects without depressive symptoms, rs5993882 was identified as the SNP most likely to be related to TMD pain. In subjects with symptoms of depression, rs1544325 was the corresponding top COMT SNP . Conclusions Our results indicate that variants within the COMT gene are associated with pain perception. However, this association is highly moderated by the absence or presence of lifetime depressive symptoms." @default.
• W2149498568 created "2016-06-24" @default.
• W2149498568 creator A5011709769 @default.
• W2149498568 creator A5036535247 @default.
• W2149498568 creator A5037469384 @default.
• W2149498568 creator A5038186760 @default.
• W2149498568 creator A5039866909 @default.
• W2149498568 creator A5054140739 @default.
• W2149498568 creator A5059371186 @default.
• W2149498568 creator A5069535659 @default.
• W2149498568 creator A5075092196 @default.
• W2149498568 creator A5079797502 @default.
• W2149498568 creator A5081670625 @default.
• W2149498568 date "2011-12-19" @default.
• W2149498568 modified "2023-10-18" @default.
• W2149498568 title "The effect of catechol-O-methyltransferase polymorphisms on pain is modified by depressive symptoms" @default.
• W2149498568 cites W1608258930 @default.
• W2149498568 cites W1698622206 @default.
• W2149498568 cites W1913428799 @default.
• W2149498568 cites W1973128804 @default.
• W2149498568 cites W1973826686 @default.
• W2149498568 cites W1974167091 @default.
• W2149498568 cites W1977463651 @default.
• W2149498568 cites W1978808059 @default.
• W2149498568 cites W1985482278 @default.
• W2149498568 cites W1989068577 @default.
• W2149498568 cites W1995458911 @default.
• W2149498568 cites W2004934852 @default.
• W2149498568 cites W2015445948 @default.
• W2149498568 cites W2015832363 @default.
• W2149498568 cites W2019192578 @default.
• W2149498568 cites W2028407638 @default.
• W2149498568 cites W2030705868 @default.
• W2149498568 cites W2032273455 @default.
• W2149498568 cites W2038709220 @default.
• W2149498568 cites W2049595315 @default.
• W2149498568 cites W2057283131 @default.
• W2149498568 cites W2076010599 @default.
• W2149498568 cites W2076620343 @default.
• W2149498568 cites W2078292330 @default.
• W2149498568 cites W2085320151 @default.
• W2149498568 cites W2085329425 @default.
• W2149498568 cites W2086510608 @default.
• W2149498568 cites W2088504456 @default.
• W2149498568 cites W2090368839 @default.
• W2149498568 cites W2103637716 @default.
• W2149498568 cites W2111870353 @default.
• W2149498568 cites W2114552460 @default.
• W2149498568 cites W2115493377 @default.
• W2149498568 cites W2119805860 @default.
• W2149498568 cites W2126983199 @default.
• W2149498568 cites W2131394216 @default.
• W2149498568 cites W2132048168 @default.
• W2149498568 cites W2135124628 @default.
• W2149498568 cites W2140703131 @default.
• W2149498568 cites W2144101679 @default.
• W2149498568 cites W2146481987 @default.
• W2149498568 cites W2148694444 @default.
• W2149498568 cites W2161375784 @default.
• W2149498568 cites W2162530578 @default.
• W2149498568 cites W2268611469 @default.
• W2149498568 cites W4245265600 @default.
• W2149498568 doi "https://doi.org/10.1002/j.1532-2149.2011.00067.x" @default.
• W2149498568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22337325" @default.
• W2149498568 hasPublicationYear "2011" @default.
• W2149498568 type Work @default.
• W2149498568 sameAs 2149498568 @default.
• W2149498568 citedByCount "12" @default.
• W2149498568 countsByYear W21494985682012 @default.
• W2149498568 countsByYear W21494985682014 @default.
• W2149498568 countsByYear W21494985682015 @default.
• W2149498568 countsByYear W21494985682016 @default.
• W2149498568 countsByYear W21494985682017 @default.
• W2149498568 countsByYear W21494985682018 @default.
• W2149498568 countsByYear W21494985682019 @default.
• W2149498568 countsByYear W21494985682020 @default.
• W2149498568 countsByYear W21494985682021 @default.
• W2149498568 crossrefType "journal-article" @default.
• W2149498568 hasAuthorship W2149498568A5011709769 @default.
• W2149498568 hasAuthorship W2149498568A5036535247 @default.
• W2149498568 hasAuthorship W2149498568A5037469384 @default.
• W2149498568 hasAuthorship W2149498568A5038186760 @default.
• W2149498568 hasAuthorship W2149498568A5039866909 @default.
• W2149498568 hasAuthorship W2149498568A5054140739 @default.
• W2149498568 hasAuthorship W2149498568A5059371186 @default.
• W2149498568 hasAuthorship W2149498568A5069535659 @default.
• W2149498568 hasAuthorship W2149498568A5075092196 @default.
• W2149498568 hasAuthorship W2149498568A5079797502 @default.
• W2149498568 hasAuthorship W2149498568A5081670625 @default.
• W2149498568 hasConcept C104317684 @default.
• W2149498568 hasConcept C118552586 @default.
• W2149498568 hasConcept C126322002 @default.
• W2149498568 hasConcept C135763542 @default.
• W2149498568 hasConcept C139275648 @default.
• W2149498568 hasConcept C139719470 @default.
• W2149498568 hasConcept C153209595 @default.
• W2149498568 hasConcept C15744967 @default.
• W2149498568 hasConcept C162324750 @default.

• next