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• W2149498758 abstract "Muir-Torre syndrome (MTS) is a rare autosomal-dominant genodermatosis characterized by sebaceous neoplasms and one or more visceral malignancies. Sebaceous tumors include sebaceous adenoma and carcinoma, which may be solitary or multiple. Visceral malignancies most often arise in the colorectum and endometrium. Because a subset of patients with phenotypic MTS will have germline mutations in the DNA mismatch repair genes hMSH2 and hMLH1, MTS is considered a phenotypic subtype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), in which inherited defects in DNA mismatch repair genes result in microsatellite instability. Pathologists have an important role in the early detection and initial diagnosis of MTS: identification of at-risk individuals allows appropriate screening and surveillance for visceral malignancies, thereby reducing morbidity and mortality. Herein, we describe the clinicopathologic features of MTS." @default.
• W2149498758 created "2016-06-24" @default.
• W2149498758 creator A5029874305 @default.
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• W2149498758 date "2014-12-01" @default.
• W2149498758 modified "2023-09-27" @default.
• W2149498758 title "Muir-Torre Syndrome" @default.
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• W2149498758 doi "https://doi.org/10.5858/arpa.2013-0301-rs" @default.
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