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• W2149502364 abstract "Movement of tRNA and mRNA through the ribosome is coupled. However, selection for suppression of a -1 frameshift mutation in Escherichia coli has yielded a class of mutant tRNAs that can violate this mechanism and hop or disengage from their cognate codons and re-pair downstream in the mRNA. Previously described tRNA mutants of this class included those with insertions in the anticodon of tRNA(Val)1. This report describes further tRNA(Val)1 alterations that enhance hopping; these include a novel insertion in the anticodon loop, base substitutions in the anticodon stem and a base deletion in the variable loop. These results indicate that several different features of a tRNA are important for maintaining stable codon-anticodon interactions and coupled movement of tRNA and mRNA during the elongation phase of protein synthesis." @default.
• W2149502364 created "2016-06-24" @default.
• W2149502364 creator A5056336149 @default.
• W2149502364 date "2003-10-01" @default.
• W2149502364 modified "2023-09-23" @default.
• W2149502364 title "tRNA hopping: effects of mutant tRNAs" @default.
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• W2149502364 doi "https://doi.org/10.1016/j.bbaexp.2003.09.002" @default.
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