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- W2149502476 abstract "A large body of evidence supports the hypothesis that an infectious agent is involved in the etiology of acute lymphoblastic leukemia (ALL) in children, particularly those cases occurring in children between 2 and 5 years of age (1–4). Recently, a specific virus has been posited as a candidate etiologic agent for childhood ALL, with leukemia occurring as a consequence of primary infections of women during pregnancy that lead to in utero infection and to subsequent increased risk of developing ALL in early childhood (5). Since a critical component of this proposal is that in utero infection by a leukemiainducing agent is the first step in development of many cases of childhood ALL, we were interested to see if a mathematical model with clinically reasonable parameters in which the critical leukemogenic event occurred in utero could be developed to explain the observed incidence of ALL among young children in the United States. We examined models that represented the age at diagnosis of ALL as the sum of two time intervals. The first is the time from birth until the occurrence of an event that completes the neoplastic transformation in infants that was initiated in utero. The second time is the latent time from neoplastic transformation to clinical detection. Let the probability density function of the first time be denoted by f1( ) and the probability density function of the latent time to clinical detection be denoted by f2( ). We assume that these two time intervals are independent. Hence, the probability that leukemia is detected at time t in a child who experienced an initiating event prior to birth can be represented as" @default.
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- W2149502476 date "1997-10-15" @default.
- W2149502476 modified "2023-10-16" @default.
- W2149502476 title "Age-Specific Incidence of Acute Lymphoblastic Leukemia in U.S. Children: In Utero Initiation Model" @default.
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- W2149502476 doi "https://doi.org/10.1093/jnci/89.20.1542" @default.
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