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• W2149503239 abstract "<h3>Objective:</h3> To investigate the response to different strength training techniques of growth and myogenic factors in human skeletal muscle, with particular emphasis on satellite cell (SC) activation. <h3>Methods:</h3> 24 volunteers were divided into two groups and performed a 6-week strength training (group A trained with maximum contraction and group B had training combined with maximum contractions, ballistic movement and stretching–shortening cycles). Muscle biopsies were obtained from triceps brachii 3 days before and 7 days after training. For estimating gene expression of insulin-like growth factor (IGF-1), mechano growth factor (MGF), MyoD and myogenin, real-time RT-PCR was performed. <h3>Results:</h3> In group A, there was an increase in the 1 repeat maximum (1RM), but no change in V_max (maximum movement velocity) and an increase in MHC (myosin heavy chain) IIa and a decrease in MHC IIx; in group B both 1RM and V_max increased significantly along with an increase in MHC IIa and a decrease in MHC I. The MGF gene expression increased significantly in both groups (by 1160% and 59%, respectively), and IGF-1 increased only in group A (by 335%). MyoD and myogenin gene expression increased in group A (by 107% and 94%, respectively) but did not change in group B. <h3>Conclusions:</h3> Response of growth and myogenic factors occurs during muscular adaptation to a prolonged training, and strength training with different strategies caused different responses with respect to gene expression of these factors. These results suggest that SC activation is involved in the muscular adaptation process to training and might be attributed to MHC isoform transition." @default.
• W2149503239 created "2016-06-24" @default.
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• W2149503239 date "2007-11-29" @default.
• W2149503239 modified "2023-10-15" @default.
• W2149503239 title "Response of growth and myogenic factors in human skeletal muscle to strength training" @default.
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• W2149503239 doi "https://doi.org/10.1136/bjsm.2007.045518" @default.
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