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- W2149512712 abstract "Five cases of cutaneous carcinoma occurred during long-term hydroxyurea therapy. Herein the responsibility of this drug in the onset of the tumors will be discussed. <h3>Report of Cases.</h3> Five white patients with skin photo-type II or III, were living in France and had no history of cutaneous carcinoma before treatment (<b>Table 1</b>and<b>Table 2</b>). The patients received hydroxyurea for 2 to 10 years (mean, 6½ years), with cumulative dosesbetween 650 and 3600 g. The patients' mean age was 71 years. Cutaneous carcinomas are actually frequent in the eighth decade of life; nevertheless, we suspect hydroxyurea of having a cutaneous carcinogenic effect in these patients, although it is now impossible to prove this. Indeed, our attention was drawn because of the sudden onset of tumors over a few weeks in patient 1, the large number and size of tumors in patients 2 and 5, and the remarkable absence of" @default.
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- W2149512712 date "1996-11-01" @default.
- W2149512712 modified "2023-10-13" @default.
- W2149512712 title "Cutaneous Carcinoma During Long-term Hydroxyurea Therapy: A Report of 5 Cases" @default.
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- W2149512712 doi "https://doi.org/10.1001/archderm.1996.03890350139035" @default.
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