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• W2149519103 abstract "The effects of changes in intraneuronal levels of 5-HT induced by monoamine oxidase inhibitors (MAOI) given in vivo or exogenous 5-HT added in vitro on 5-HT synthesis in striatal slices of the rat have been examined. The synthesis of 5-HT was estimated by the measurement of the total formation of [3H]5-HT and [3H]5-hydroxyindole acetic acid from [3H]tryptophan and by calculation of the conversion index (CI) of tryptophan into 5-HT. The small formation of [3H]tryptamine and [3H]indole acetic acid from [3H]tryptophan was taken into account in the estimation of 5-HT synthesis. Both MAOI pretreament (180 min) and 5-HT (2·8 μM) inhibited synthesis. The latter effect persisted in catecholamine depleted tissues and was related to intraneuronal changes in 5-HT levels, since it could be prevented by chlorimipramine. The inhibition of 5-HT synthesis was related to the decreased conversion of tryptophan into 5-hydroxytryptophan and could not be prevented by p-chloro-phenylalanine pretreatment which depleted 5-HT levels or by dibutyryl cyclic AMP which normally stimulated 5-HT synthesis. Tryptophan uptake in slices was not affected by exogenous 5-HT. The various mechanisms possibly involved in the end product regulation process of 5-HT synthesis are discussed." @default.
• W2149519103 created "2016-06-24" @default.
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• W2149519103 date "1973-06-01" @default.
• W2149519103 modified "2023-10-01" @default.
• W2149519103 title "FEEDBACK REGULATION OF 5-HT SYNTHESIS IN RAT STRIATAL SLICES" @default.
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• W2149519103 doi "https://doi.org/10.1111/j.1471-4159.1973.tb00288.x" @default.
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