Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149521870> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2149521870 endingPage "876" @default.
- W2149521870 startingPage "866" @default.
- W2149521870 abstract "The study was aimed at determining the acid dissociation constant of cryptolepine hydrochloride and its degradation under stressed conditions. The pKa was determined using buffers in the pH range 10.4–11.6 by spectrophotometry at controlled measurement temperature (20 ± 0.5°C). The stability of the compound was investigated under various stressed conditions including neutral, acid, alkaline, light, dry heat and oxidation at different temperatures. Degradation products were analysed by HPLC. The calculated pKa values (uncorrected and corrected for ionic strength) were 11.09 ± 0.03 and 10.99 ± 0.05, respectively. A graphical approach yielded an uncorrected pKa value of 11.07. Degradation of the compound in water, 0.1 M HCl, 0.1 M NaOH and 3% hydrogen peroxide followed a first order reaction. With proper temperature control and maintenance of uniform ionic strength, a reproducible pKa of cryptolepine is obtainable by spectrophotometry. The compound was found to be highly susceptible to oxidation and relatively stable in neutral and acidic conditions but less so in a basic medium. There were no significant changes in concentration of samples exposed to light and dry heat at 60°C over the study period." @default.
- W2149521870 created "2016-06-24" @default.
- W2149521870 creator A5008866887 @default.
- W2149521870 creator A5032767792 @default.
- W2149521870 creator A5043992105 @default.
- W2149521870 creator A5083816147 @default.
- W2149521870 date "2012-03-22" @default.
- W2149521870 modified "2023-09-27" @default.
- W2149521870 title "Determination of pKa and forced degradation of the indoloquinoline antimalarial compound cryptolepine hydrochloride" @default.
- W2149521870 cites W1547368610 @default.
- W2149521870 cites W1988768527 @default.
- W2149521870 cites W1993817579 @default.
- W2149521870 cites W1998811109 @default.
- W2149521870 cites W2000818398 @default.
- W2149521870 cites W2003013170 @default.
- W2149521870 cites W2011950180 @default.
- W2149521870 cites W2016593534 @default.
- W2149521870 cites W2026641599 @default.
- W2149521870 cites W2047688102 @default.
- W2149521870 cites W2052277746 @default.
- W2149521870 cites W2054210256 @default.
- W2149521870 cites W2055426362 @default.
- W2149521870 cites W2058590672 @default.
- W2149521870 cites W2067010736 @default.
- W2149521870 cites W2071988756 @default.
- W2149521870 cites W2080714773 @default.
- W2149521870 cites W2088177843 @default.
- W2149521870 cites W2089018653 @default.
- W2149521870 cites W2142331718 @default.
- W2149521870 cites W2154484502 @default.
- W2149521870 cites W2492101850 @default.
- W2149521870 cites W4232455396 @default.
- W2149521870 cites W4236739160 @default.
- W2149521870 cites W4247172093 @default.
- W2149521870 doi "https://doi.org/10.3109/10837450.2012.668554" @default.
- W2149521870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22436019" @default.
- W2149521870 hasPublicationYear "2012" @default.
- W2149521870 type Work @default.
- W2149521870 sameAs 2149521870 @default.
- W2149521870 citedByCount "5" @default.
- W2149521870 countsByYear W21495218702016 @default.
- W2149521870 countsByYear W21495218702017 @default.
- W2149521870 countsByYear W21495218702020 @default.
- W2149521870 countsByYear W21495218702021 @default.
- W2149521870 crossrefType "journal-article" @default.
- W2149521870 hasAuthorship W2149521870A5008866887 @default.
- W2149521870 hasAuthorship W2149521870A5032767792 @default.
- W2149521870 hasAuthorship W2149521870A5043992105 @default.
- W2149521870 hasAuthorship W2149521870A5083816147 @default.
- W2149521870 hasConcept C13965031 @default.
- W2149521870 hasConcept C178790620 @default.
- W2149521870 hasConcept C179104552 @default.
- W2149521870 hasConcept C184651966 @default.
- W2149521870 hasConcept C185592680 @default.
- W2149521870 hasConcept C187428577 @default.
- W2149521870 hasConcept C22163223 @default.
- W2149521870 hasConcept C2776460385 @default.
- W2149521870 hasConcept C2779679103 @default.
- W2149521870 hasConcept C2780343419 @default.
- W2149521870 hasConcept C41008148 @default.
- W2149521870 hasConcept C43617362 @default.
- W2149521870 hasConcept C533411734 @default.
- W2149521870 hasConcept C76155785 @default.
- W2149521870 hasConceptScore W2149521870C13965031 @default.
- W2149521870 hasConceptScore W2149521870C178790620 @default.
- W2149521870 hasConceptScore W2149521870C179104552 @default.
- W2149521870 hasConceptScore W2149521870C184651966 @default.
- W2149521870 hasConceptScore W2149521870C185592680 @default.
- W2149521870 hasConceptScore W2149521870C187428577 @default.
- W2149521870 hasConceptScore W2149521870C22163223 @default.
- W2149521870 hasConceptScore W2149521870C2776460385 @default.
- W2149521870 hasConceptScore W2149521870C2779679103 @default.
- W2149521870 hasConceptScore W2149521870C2780343419 @default.
- W2149521870 hasConceptScore W2149521870C41008148 @default.
- W2149521870 hasConceptScore W2149521870C43617362 @default.
- W2149521870 hasConceptScore W2149521870C533411734 @default.
- W2149521870 hasConceptScore W2149521870C76155785 @default.
- W2149521870 hasIssue "4" @default.
- W2149521870 hasLocation W21495218701 @default.
- W2149521870 hasLocation W21495218702 @default.
- W2149521870 hasOpenAccess W2149521870 @default.
- W2149521870 hasPrimaryLocation W21495218701 @default.
- W2149521870 hasRelatedWork W2006883166 @default.
- W2149521870 hasRelatedWork W2029265473 @default.
- W2149521870 hasRelatedWork W2030670202 @default.
- W2149521870 hasRelatedWork W2036110988 @default.
- W2149521870 hasRelatedWork W2042013638 @default.
- W2149521870 hasRelatedWork W2047005256 @default.
- W2149521870 hasRelatedWork W2084503887 @default.
- W2149521870 hasRelatedWork W2371957921 @default.
- W2149521870 hasRelatedWork W2952785262 @default.
- W2149521870 hasRelatedWork W4385217528 @default.
- W2149521870 hasVolume "18" @default.
- W2149521870 isParatext "false" @default.
- W2149521870 isRetracted "false" @default.
- W2149521870 magId "2149521870" @default.
- W2149521870 workType "article" @default.