FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149551094> ?p ?o ?g. }

• W2149551094 endingPage "521" @default.
• W2149551094 startingPage "514" @default.
• W2149551094 abstract "Aberrant phosphorylation of neurofilaments, similar to that occurring in various motor neuron diseases, is produced in cultured motor neurons by activation of protein kinase C (PKC). Following exposure to synthetic diacylglycerol, persistent change in the phosphorylation state of C-terminal domains of neurofilament proteins was detected by increased perikaryal immunoreactivity with the antibody SMI34; this antibody recognizes NF-M/NF-H when C-terminal KSP repeat domains are highly phosphorylated. SMI34 labeling of perikarya and dendrites was prevented by pretreatment with either the NMDA receptor antagonist APV or by the Ca2+/calmodulin-dependent protein kinase (CaMK) inhibitor KN-62, but not by antagonists of AMPA/kainate or metabotropic glutamate receptors or by inhibitors of arachidonic acid metabolic pathways. Thus, activation of PKC may induce neurofilament phosphorylation in motor neurons by acting in cooperation with stimulation of NMDA receptors and activation of CaMK. These mechanisms may be relevant to motor neuron disease and other neuronal injuries in which increased PKC activity has been measured. J. Neurosci. Res. 50:514–521, 1997. © 1997 Wiley-Liss, Inc." @default.
• W2149551094 created "2016-06-24" @default.
• W2149551094 creator A5007964844 @default.
• W2149551094 creator A5021069827 @default.
• W2149551094 date "1997-11-15" @default.
• W2149551094 modified "2023-09-26" @default.
• W2149551094 title "Activation of NMDA receptors and Ca2+/calmodulin-dependent protein kinase participate in phosphorylation of neurofilaments induced by protein kinase C" @default.
• W2149551094 cites W1501475405 @default.
• W2149551094 cites W1515547441 @default.
• W2149551094 cites W1518396254 @default.
• W2149551094 cites W1568484052 @default.
• W2149551094 cites W1580590749 @default.
• W2149551094 cites W1580740260 @default.
• W2149551094 cites W1587523336 @default.
• W2149551094 cites W1599213556 @default.
• W2149551094 cites W1601155059 @default.
• W2149551094 cites W1639403002 @default.
• W2149551094 cites W1781119783 @default.
• W2149551094 cites W1967024359 @default.
• W2149551094 cites W1970520842 @default.
• W2149551094 cites W1971639674 @default.
• W2149551094 cites W1977098380 @default.
• W2149551094 cites W1978348298 @default.
• W2149551094 cites W1978991443 @default.
• W2149551094 cites W1981996056 @default.
• W2149551094 cites W1988925006 @default.
• W2149551094 cites W1989029253 @default.
• W2149551094 cites W1989800221 @default.
• W2149551094 cites W1990217338 @default.
• W2149551094 cites W1994195148 @default.
• W2149551094 cites W199761710 @default.
• W2149551094 cites W2016960303 @default.
• W2149551094 cites W2017761762 @default.
• W2149551094 cites W2039753614 @default.
• W2149551094 cites W2040672001 @default.
• W2149551094 cites W2041662644 @default.
• W2149551094 cites W2045807655 @default.
• W2149551094 cites W2046208200 @default.
• W2149551094 cites W2047593069 @default.
• W2149551094 cites W2052086914 @default.
• W2149551094 cites W2055864719 @default.
• W2149551094 cites W2058117427 @default.
• W2149551094 cites W2068229306 @default.
• W2149551094 cites W2068502127 @default.
• W2149551094 cites W2068973094 @default.
• W2149551094 cites W2070497389 @default.
• W2149551094 cites W2071940267 @default.
• W2149551094 cites W2074568005 @default.
• W2149551094 cites W2076728391 @default.
• W2149551094 cites W2077348695 @default.
• W2149551094 cites W2079555764 @default.
• W2149551094 cites W2080017484 @default.
• W2149551094 cites W2089544502 @default.
• W2149551094 cites W2091693735 @default.
• W2149551094 cites W2092279211 @default.
• W2149551094 cites W2093033434 @default.
• W2149551094 cites W2115522774 @default.
• W2149551094 cites W2117834405 @default.
• W2149551094 cites W2126578889 @default.
• W2149551094 cites W2139748951 @default.
• W2149551094 cites W2149497936 @default.
• W2149551094 cites W2153870748 @default.
• W2149551094 cites W2314689571 @default.
• W2149551094 doi "https://doi.org/10.1002/(sici)1097-4547(19971115)50:4<514::aid-jnr2>3.0.co;2-h" @default.
• W2149551094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9404713" @default.
• W2149551094 hasPublicationYear "1997" @default.
• W2149551094 type Work @default.
• W2149551094 sameAs 2149551094 @default.
• W2149551094 citedByCount "4" @default.
• W2149551094 countsByYear W21495510942021 @default.
• W2149551094 crossrefType "journal-article" @default.
• W2149551094 hasAuthorship W2149551094A5007964844 @default.
• W2149551094 hasAuthorship W2149551094A5021069827 @default.
• W2149551094 hasConcept C11960822 @default.
• W2149551094 hasConcept C157207234 @default.
• W2149551094 hasConcept C160268369 @default.
• W2149551094 hasConcept C169760540 @default.
• W2149551094 hasConcept C170493617 @default.
• W2149551094 hasConcept C185592680 @default.
• W2149551094 hasConcept C195794163 @default.
• W2149551094 hasConcept C203014093 @default.
• W2149551094 hasConcept C204232928 @default.
• W2149551094 hasConcept C2776752467 @default.
• W2149551094 hasConcept C2780775167 @default.
• W2149551094 hasConcept C55493867 @default.
• W2149551094 hasConcept C61174792 @default.
• W2149551094 hasConcept C67018056 @default.
• W2149551094 hasConcept C86803240 @default.
• W2149551094 hasConcept C95444343 @default.
• W2149551094 hasConceptScore W2149551094C11960822 @default.
• W2149551094 hasConceptScore W2149551094C157207234 @default.
• W2149551094 hasConceptScore W2149551094C160268369 @default.
• W2149551094 hasConceptScore W2149551094C169760540 @default.
• W2149551094 hasConceptScore W2149551094C170493617 @default.
• W2149551094 hasConceptScore W2149551094C185592680 @default.
• W2149551094 hasConceptScore W2149551094C195794163 @default.
• W2149551094 hasConceptScore W2149551094C203014093 @default.
• W2149551094 hasConceptScore W2149551094C204232928 @default.

• next