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• W2149558153 abstract "No AccessJournal of UrologyPediatric Urology1 Nov 2011Safety, Efficacy and Health Related Quality of Life of Autologous Myoblast Transplantation for Treatment of Urinary Incontinence in Children With Bladder Exstrophy-Epispadias Complex Azadeh Elmi, Abdol-Mohammad Kajbafzadeh, Ali Tourchi, Saman Shafaat Talab, and Shadi Abdar Esfahani Azadeh ElmiAzadeh Elmi More articles by this author , Abdol-Mohammad KajbafzadehAbdol-Mohammad Kajbafzadeh More articles by this author , Ali TourchiAli Tourchi More articles by this author , Saman Shafaat TalabSaman Shafaat Talab More articles by this author , and Shadi Abdar EsfahaniShadi Abdar Esfahani More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.07.029AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Children with bladder exstrophy-epispadias complex undergoing endourethral autologous myoblast transplantation to treat urinary incontinence were evaluated at 4 years of followup regarding the safety, efficacy and durability of the procedure, and health related quality of life. Materials and Methods: Seven boys underwent autologous myoblast transplantation between May and December 2006. All patients had persistent urinary incontinence after bladder neck reconstruction and bulking agent injection. Patients were followed for 4 years after autologous myoblast transplantation regarding clinical outcomes and cystometric, urodynamic, uroflowmetric and urethrocystoscopic evaluations. Health related quality of life was also measured before treatment and at final followup. Results: No evidence of urinary obstruction was observed. Five children (71%) were completely continent and 2 (29%) were socially dry with complete daytime dryness at final followup. Health related quality of life was improved significantly. Urodynamic studies revealed a progressive increase in bladder capacity (p <0.001). Mean detrusor leak point pressure showed a 27 cm H2O (158%) increase during 4-year followup. Uroflowmetry parameters of voided volume and average maximum flow rate were improved significantly (p <0.001). Conclusions: The 4-year outcomes demonstrate that autologous myoblast transplantation for urinary incontinence in children with bladder exstrophy-epispadias complex is relatively reliable, reproducible, safe and effective with minimal morbidity. This novel treatment represents a promising therapeutic approach in patients with urinary incontinence. Further randomized trials with larger numbers of patients and longer followup are needed. References 1 : Exstrophy-epispadias complex. In: . Edited by . Philadelphia: WB Saunders Co2007: 3497. Google Scholar 2 : Complete primary repair of bladder exstrophy in children presenting late and those with failed initial closure: single center experience. J Urol2005; 174: 1549. Link, Google Scholar 3 : Outcome of complete primary BEEC repair: single-center experience. J Pediatr Urol2009; 5: 496. 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Google Scholar Pediatric Urology Research Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran© 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byPeters K, Dmochowski R, Carr L, Robert M, Kaufman M, Sirls L, Herschorn S, Birch C, Kultgen P and Chancellor M (2018) Autologous Muscle Derived Cells for Treatment of Stress Urinary Incontinence in WomenJournal of Urology, VOL. 192, NO. 2, (469-476), Online publication date: 1-Aug-2014.Gräs S, Klarskov N and Lose G (2018) Intraurethral Injection of Autologous Minced Skeletal Muscle: A Simple Surgical Treatment for Stress Urinary IncontinenceJournal of Urology, VOL. 192, NO. 3, (850-855), Online publication date: 1-Sep-2014. Volume 186Issue 5November 2011Page: 2021-2026 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordsmyoblastsstem cellsbladder exstrophyquality of lifeurinary incontinenceAcknowledgmentsKiana Kajbafzadeh, University of British Columbia, provided assistance with the manuscript. Dr. M. J. Mohseni conducted independent patient reevaluations and interviews.MetricsAuthor Information Azadeh Elmi More articles by this author Abdol-Mohammad Kajbafzadeh More articles by this author Ali Tourchi More articles by this author Saman Shafaat Talab More articles by this author Shadi Abdar Esfahani More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W2149558153 title "Safety, Efficacy and Health Related Quality of Life of Autologous Myoblast Transplantation for Treatment of Urinary Incontinence in Children With Bladder Exstrophy-Epispadias Complex" @default.
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