FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149558652> ?p ?o ?g. }

• W2149558652 endingPage "1064" @default.
• W2149558652 startingPage "1051" @default.
• W2149558652 abstract "Animal genomes each encode multiple highly conserved actin isoforms that polymerize to form the microfilament cytoskeleton. Previous studies of vertebrates and invertebrates have shown that many actin isoforms are restricted to either nonmuscle (cytoplasmic) functions, or to myofibril force generation in muscle cells. We have identified two temperature-sensitive and semidominant embryonic-lethal Caenorhabditis elegans mutants, each with a single mis-sense mutation in act-2, one of five C. elegans genes that encode actin isoforms. These mutations alter conserved and adjacent amino acids predicted to form part of the ATP binding pocket of actin. At the restrictive temperature, both mutations resulted in aberrant distributions of cortical microfilaments associated with abnormal and striking membrane ingressions and protrusions. In contrast to the defects caused by these dominant mis-sense mutations, an act-2 deletion did not result in early embryonic cell division defects, suggesting that additional and redundant actin isoforms are involved. Accordingly, we found that two additional actin isoforms, act-1 and act-3, were required redundantly with act-2 for cytoplasmic function in early embryonic cells. The act-1 and -3 genes also have been implicated previously in muscle function. We found that an ACT-2::GFP reporter was expressed cytoplasmically in embryonic cells and also was incorporated into contractile filaments in adult muscle cells. Furthermore, one of the dominant act-2 mutations resulted in uncoordinated adult movement. We conclude that redundant C. elegans actin isoforms function in both muscle and nonmuscle contractile processes." @default.
• W2149558652 created "2016-06-24" @default.
• W2149558652 creator A5025033391 @default.
• W2149558652 creator A5039596752 @default.
• W2149558652 creator A5041477298 @default.
• W2149558652 creator A5068671796 @default.
• W2149558652 date "2006-03-01" @default.
• W2149558652 modified "2023-09-27" @default.
• W2149558652 title "Conditional Dominant Mutations in the<i>Caenorhabditis elegans</i>Gene<i>act-2</i>Identify Cytoplasmic and Muscle Roles for a Redundant Actin Isoform" @default.
• W2149558652 cites W1521518663 @default.
• W2149558652 cites W1595932129 @default.
• W2149558652 cites W1845343606 @default.
• W2149558652 cites W1854688115 @default.
• W2149558652 cites W1944127002 @default.
• W2149558652 cites W1981231195 @default.
• W2149558652 cites W1985353915 @default.
• W2149558652 cites W2015468345 @default.
• W2149558652 cites W2015852214 @default.
• W2149558652 cites W2016831365 @default.
• W2149558652 cites W2020956640 @default.
• W2149558652 cites W2021228580 @default.
• W2149558652 cites W2023108094 @default.
• W2149558652 cites W2032093562 @default.
• W2149558652 cites W2033477896 @default.
• W2149558652 cites W2036742579 @default.
• W2149558652 cites W2036870980 @default.
• W2149558652 cites W2037634298 @default.
• W2149558652 cites W2046735987 @default.
• W2149558652 cites W2050072642 @default.
• W2149558652 cites W2053249751 @default.
• W2149558652 cites W2058382651 @default.
• W2149558652 cites W2061986589 @default.
• W2149558652 cites W2065431469 @default.
• W2149558652 cites W2069077125 @default.
• W2149558652 cites W2069290889 @default.
• W2149558652 cites W2071399936 @default.
• W2149558652 cites W2079060327 @default.
• W2149558652 cites W2079314940 @default.
• W2149558652 cites W2079706737 @default.
• W2149558652 cites W2080942738 @default.
• W2149558652 cites W2084326210 @default.
• W2149558652 cites W2088591856 @default.
• W2149558652 cites W2096358322 @default.
• W2149558652 cites W2103966138 @default.
• W2149558652 cites W2112044370 @default.
• W2149558652 cites W2112787865 @default.
• W2149558652 cites W2116581900 @default.
• W2149558652 cites W2122163057 @default.
• W2149558652 cites W2130271928 @default.
• W2149558652 cites W2140040046 @default.
• W2149558652 cites W2150080396 @default.
• W2149558652 cites W2150852081 @default.
• W2149558652 cites W2158016476 @default.
• W2149558652 cites W2165799695 @default.
• W2149558652 cites W2166254523 @default.
• W2149558652 cites W2167593678 @default.
• W2149558652 cites W2168051144 @default.
• W2149558652 cites W2417702944 @default.
• W2149558652 cites W4247000966 @default.
• W2149558652 cites W69268942 @default.
• W2149558652 doi "https://doi.org/10.1091/mbc.e05-09-0886" @default.
• W2149558652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1382297" @default.
• W2149558652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16407404" @default.
• W2149558652 hasPublicationYear "2006" @default.
• W2149558652 type Work @default.
• W2149558652 sameAs 2149558652 @default.
• W2149558652 citedByCount "34" @default.
• W2149558652 countsByYear W21495586522012 @default.
• W2149558652 countsByYear W21495586522013 @default.
• W2149558652 countsByYear W21495586522014 @default.
• W2149558652 countsByYear W21495586522017 @default.
• W2149558652 countsByYear W21495586522018 @default.
• W2149558652 countsByYear W21495586522019 @default.
• W2149558652 countsByYear W21495586522020 @default.
• W2149558652 countsByYear W21495586522021 @default.
• W2149558652 countsByYear W21495586522022 @default.
• W2149558652 countsByYear W21495586522023 @default.
• W2149558652 crossrefType "journal-article" @default.
• W2149558652 hasAuthorship W2149558652A5025033391 @default.
• W2149558652 hasAuthorship W2149558652A5039596752 @default.
• W2149558652 hasAuthorship W2149558652A5041477298 @default.
• W2149558652 hasAuthorship W2149558652A5068671796 @default.
• W2149558652 hasBestOaLocation W21495586522 @default.
• W2149558652 hasConcept C104317684 @default.
• W2149558652 hasConcept C125705527 @default.
• W2149558652 hasConcept C142669718 @default.
• W2149558652 hasConcept C1491633281 @default.
• W2149558652 hasConcept C189040839 @default.
• W2149558652 hasConcept C190062978 @default.
• W2149558652 hasConcept C2778944004 @default.
• W2149558652 hasConcept C53345823 @default.
• W2149558652 hasConcept C54355233 @default.
• W2149558652 hasConcept C6997183 @default.
• W2149558652 hasConcept C86803240 @default.
• W2149558652 hasConcept C95444343 @default.
• W2149558652 hasConceptScore W2149558652C104317684 @default.
• W2149558652 hasConceptScore W2149558652C125705527 @default.
• W2149558652 hasConceptScore W2149558652C142669718 @default.

• next