Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149573012> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2149573012 endingPage "e233" @default.
- W2149573012 startingPage "e233" @default.
- W2149573012 abstract "DNA methyltransferases (DNMTs) are epigenetic regulators targeted to the treatment of hematological malignancies.1, 2, 3, 4 Mutations in the DNA methyltransferase DNMT3A and high expression of its paralogue DNMT3B have been associated with inferior outcome in acute myeloid leukemia (AML) and other hematological malignancies.5, 6, 7, 8 Using a publicly available gene expression data set,9 we studied whether DNMT3B expression correlates with outcome in genetically well-defined AML subgroups. We first validated the expression data from the microarray by quantitative PCR, using 39 patient samples (Supplementary Figure S1A). DNMT3B micro-array analyses showed that the expression was not normally distributed among AML patients; in the quartile with highest expression, a larger variation in expression was observed compared to the three quartiles with relatively lower expression (Supplementary Figure S1B). The median DNMT3B expression in AML samples was significantly lower compared with that observed in normal bone marrow (NBM)-derived CD34+ cells (P 60 years; white blood cell counts >100 × 109/l; transplantation status; karyotypes t(8;21), t(15;17) and inv(16); nucleophosmin 1 (NPM1), FLT3-ITD, DNMT3A and double CEBPA mutations, and ecotropic viral integration site 1 (EVI1) overexpression), which revealed that higher DNMT3B expression carried an independent prognostic risk for both OS and EFS (hazard ratio (HR): 1.768, 95% confidence interval (CI): 1.384–2.260; P<0.001 and HR: 1.706, 95% CI: 1.342–2.168; P<0.001, respectively, Table 1), in line with a recently published study.7 In fact, higher DNMT3B expression showed a higher hazard ratio for OS than that of well-known adverse prognostic factors such as internal tandem duplications of the fms-related tyrosine kinase 3 (FLT3-ITD, HR: 1.675, 95% CI: 1.287–2.179; P<0.001) and overexpression of the EVI1 gene (HR: 1.430, 95% CI: 0.999–2.047; P=0.051)." @default.
- W2149573012 created "2016-06-24" @default.
- W2149573012 creator A5020940867 @default.
- W2149573012 creator A5025708775 @default.
- W2149573012 creator A5033586033 @default.
- W2149573012 creator A5050125183 @default.
- W2149573012 creator A5076924980 @default.
- W2149573012 creator A5077845462 @default.
- W2149573012 date "2014-08-01" @default.
- W2149573012 modified "2023-10-09" @default.
- W2149573012 title "High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations" @default.
- W2149573012 cites W1965113891 @default.
- W2149573012 cites W1978788671 @default.
- W2149573012 cites W1990870968 @default.
- W2149573012 cites W1999433714 @default.
- W2149573012 cites W2043216151 @default.
- W2149573012 cites W2054111192 @default.
- W2149573012 cites W2071981907 @default.
- W2149573012 cites W2082099618 @default.
- W2149573012 cites W2083462343 @default.
- W2149573012 cites W2086492419 @default.
- W2149573012 cites W2095066915 @default.
- W2149573012 cites W2109554035 @default.
- W2149573012 cites W2152786876 @default.
- W2149573012 doi "https://doi.org/10.1038/bcj.2014.51" @default.
- W2149573012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4219473" @default.
- W2149573012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25083817" @default.
- W2149573012 hasPublicationYear "2014" @default.
- W2149573012 type Work @default.
- W2149573012 sameAs 2149573012 @default.
- W2149573012 citedByCount "3" @default.
- W2149573012 countsByYear W21495730122015 @default.
- W2149573012 countsByYear W21495730122017 @default.
- W2149573012 crossrefType "journal-article" @default.
- W2149573012 hasAuthorship W2149573012A5020940867 @default.
- W2149573012 hasAuthorship W2149573012A5025708775 @default.
- W2149573012 hasAuthorship W2149573012A5033586033 @default.
- W2149573012 hasAuthorship W2149573012A5050125183 @default.
- W2149573012 hasAuthorship W2149573012A5076924980 @default.
- W2149573012 hasAuthorship W2149573012A5077845462 @default.
- W2149573012 hasBestOaLocation W21495730121 @default.
- W2149573012 hasConcept C104317684 @default.
- W2149573012 hasConcept C126322002 @default.
- W2149573012 hasConcept C143998085 @default.
- W2149573012 hasConcept C2483381 @default.
- W2149573012 hasConcept C2778461978 @default.
- W2149573012 hasConcept C2778729363 @default.
- W2149573012 hasConcept C30481170 @default.
- W2149573012 hasConcept C33288867 @default.
- W2149573012 hasConcept C501734568 @default.
- W2149573012 hasConcept C502942594 @default.
- W2149573012 hasConcept C53226629 @default.
- W2149573012 hasConcept C54355233 @default.
- W2149573012 hasConcept C552990157 @default.
- W2149573012 hasConcept C60644358 @default.
- W2149573012 hasConcept C71924100 @default.
- W2149573012 hasConcept C86803240 @default.
- W2149573012 hasConcept C91965660 @default.
- W2149573012 hasConceptScore W2149573012C104317684 @default.
- W2149573012 hasConceptScore W2149573012C126322002 @default.
- W2149573012 hasConceptScore W2149573012C143998085 @default.
- W2149573012 hasConceptScore W2149573012C2483381 @default.
- W2149573012 hasConceptScore W2149573012C2778461978 @default.
- W2149573012 hasConceptScore W2149573012C2778729363 @default.
- W2149573012 hasConceptScore W2149573012C30481170 @default.
- W2149573012 hasConceptScore W2149573012C33288867 @default.
- W2149573012 hasConceptScore W2149573012C501734568 @default.
- W2149573012 hasConceptScore W2149573012C502942594 @default.
- W2149573012 hasConceptScore W2149573012C53226629 @default.
- W2149573012 hasConceptScore W2149573012C54355233 @default.
- W2149573012 hasConceptScore W2149573012C552990157 @default.
- W2149573012 hasConceptScore W2149573012C60644358 @default.
- W2149573012 hasConceptScore W2149573012C71924100 @default.
- W2149573012 hasConceptScore W2149573012C86803240 @default.
- W2149573012 hasConceptScore W2149573012C91965660 @default.
- W2149573012 hasIssue "8" @default.
- W2149573012 hasLocation W21495730121 @default.
- W2149573012 hasLocation W21495730122 @default.
- W2149573012 hasLocation W21495730123 @default.
- W2149573012 hasLocation W21495730124 @default.
- W2149573012 hasLocation W21495730125 @default.
- W2149573012 hasOpenAccess W2149573012 @default.
- W2149573012 hasPrimaryLocation W21495730121 @default.
- W2149573012 hasRelatedWork W1998001202 @default.
- W2149573012 hasRelatedWork W1999886232 @default.
- W2149573012 hasRelatedWork W2082729079 @default.
- W2149573012 hasRelatedWork W2156781830 @default.
- W2149573012 hasRelatedWork W2161184668 @default.
- W2149573012 hasRelatedWork W2351781254 @default.
- W2149573012 hasRelatedWork W3009206022 @default.
- W2149573012 hasRelatedWork W3032161284 @default.
- W2149573012 hasRelatedWork W4243274547 @default.
- W2149573012 hasRelatedWork W4319461823 @default.
- W2149573012 hasVolume "4" @default.
- W2149573012 isParatext "false" @default.
- W2149573012 isRetracted "false" @default.
- W2149573012 magId "2149573012" @default.
- W2149573012 workType "article" @default.