FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149573313> ?p ?o ?g. }

• W2149573313 endingPage "484" @default.
• W2149573313 startingPage "480" @default.
• W2149573313 abstract "The human distal gut harbours a vast ensemble of microbes (the microbiota) that provide important metabolic capabilities, including the ability to extract energy from otherwise indigestible dietary polysaccharides. Studies of a few unrelated, healthy adults have revealed substantial diversity in their gut communities, as measured by sequencing 16S rRNA genes, yet how this diversity relates to function and to the rest of the genes in the collective genomes of the microbiota (the gut microbiome) remains obscure. Studies of lean and obese mice suggest that the gut microbiota affects energy balance by influencing the efficiency of calorie harvest from the diet, and how this harvested energy is used and stored. Here we characterize the faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers, to address how host genotype, environmental exposure and host adiposity influence the gut microbiome. Analysis of 154 individuals yielded 9,920 near full-length and 1,937,461 partial bacterial 16S rRNA sequences, plus 2.14 gigabases from their microbiomes. The results reveal that the human gut microbiome is shared among family members, but that each person's gut microbial community varies in the specific bacterial lineages present, with a comparable degree of co-variation between adult monozygotic and dizygotic twin pairs. However, there was a wide array of shared microbial genes among sampled individuals, comprising an extensive, identifiable 'core microbiome' at the gene, rather than at the organismal lineage, level. Obesity is associated with phylum-level changes in the microbiota, reduced bacterial diversity and altered representation of bacterial genes and metabolic pathways. These results demonstrate that a diversity of organismal assemblages can nonetheless yield a core microbiome at a functional level, and that deviations from this core are associated with different physiological states (obese compared with lean)." @default.
• W2149573313 created "2016-06-24" @default.
• W2149573313 creator A5027613718 @default.
• W2149573313 creator A5029144285 @default.
• W2149573313 creator A5029924011 @default.
• W2149573313 creator A5031459287 @default.
• W2149573313 creator A5033881627 @default.
• W2149573313 creator A5038876085 @default.
• W2149573313 creator A5042130650 @default.
• W2149573313 creator A5056967998 @default.
• W2149573313 creator A5061127602 @default.
• W2149573313 creator A5063884903 @default.
• W2149573313 creator A5065957984 @default.
• W2149573313 creator A5066589732 @default.
• W2149573313 creator A5070734184 @default.
• W2149573313 creator A5079232459 @default.
• W2149573313 creator A5086126509 @default.
• W2149573313 date "2008-11-30" @default.
• W2149573313 modified "2023-10-09" @default.
• W2149573313 title "A core gut microbiome in obese and lean twins" @default.
• W2149573313 cites W1546792714 @default.
• W2149573313 cites W1571319209 @default.
• W2149573313 cites W1964013868 @default.
• W2149573313 cites W1969435169 @default.
• W2149573313 cites W1971415551 @default.
• W2149573313 cites W1988925586 @default.
• W2149573313 cites W2038217946 @default.
• W2149573313 cites W2052969143 @default.
• W2149573313 cites W2055666215 @default.
• W2149573313 cites W2073332363 @default.
• W2149573313 cites W2087671769 @default.
• W2149573313 cites W2097875133 @default.
• W2149573313 cites W2104890139 @default.
• W2149573313 cites W2110182011 @default.
• W2149573313 cites W2111802622 @default.
• W2149573313 cites W2123003906 @default.
• W2149573313 cites W2127415562 @default.
• W2149573313 cites W2131186249 @default.
• W2149573313 cites W2131342905 @default.
• W2149573313 cites W2135805255 @default.
• W2149573313 cites W2142237411 @default.
• W2149573313 cites W2143980572 @default.
• W2149573313 cites W2144568881 @default.
• W2149573313 cites W2145336165 @default.
• W2149573313 cites W2151170536 @default.
• W2149573313 cites W2153562609 @default.
• W2149573313 cites W2156125289 @default.
• W2149573313 cites W2165065263 @default.
• W2149573313 cites W2166655850 @default.
• W2149573313 cites W2167062509 @default.
• W2149573313 cites W2168296283 @default.
• W2149573313 cites W2169330513 @default.
• W2149573313 cites W2319231450 @default.
• W2149573313 cites W4231900212 @default.
• W2149573313 doi "https://doi.org/10.1038/nature07540" @default.
• W2149573313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2677729" @default.
• W2149573313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19043404" @default.
• W2149573313 hasPublicationYear "2008" @default.
• W2149573313 type Work @default.
• W2149573313 sameAs 2149573313 @default.
• W2149573313 citedByCount "6486" @default.
• W2149573313 countsByYear W21495733132012 @default.
• W2149573313 countsByYear W21495733132013 @default.
• W2149573313 countsByYear W21495733132014 @default.
• W2149573313 countsByYear W21495733132015 @default.
• W2149573313 countsByYear W21495733132016 @default.
• W2149573313 countsByYear W21495733132017 @default.
• W2149573313 countsByYear W21495733132018 @default.
• W2149573313 countsByYear W21495733132019 @default.
• W2149573313 countsByYear W21495733132020 @default.
• W2149573313 countsByYear W21495733132021 @default.
• W2149573313 countsByYear W21495733132022 @default.
• W2149573313 countsByYear W21495733132023 @default.
• W2149573313 crossrefType "journal-article" @default.
• W2149573313 hasAuthorship W2149573313A5027613718 @default.
• W2149573313 hasAuthorship W2149573313A5029144285 @default.
• W2149573313 hasAuthorship W2149573313A5029924011 @default.
• W2149573313 hasAuthorship W2149573313A5031459287 @default.
• W2149573313 hasAuthorship W2149573313A5033881627 @default.
• W2149573313 hasAuthorship W2149573313A5038876085 @default.
• W2149573313 hasAuthorship W2149573313A5042130650 @default.
• W2149573313 hasAuthorship W2149573313A5056967998 @default.
• W2149573313 hasAuthorship W2149573313A5061127602 @default.
• W2149573313 hasAuthorship W2149573313A5063884903 @default.
• W2149573313 hasAuthorship W2149573313A5065957984 @default.
• W2149573313 hasAuthorship W2149573313A5066589732 @default.
• W2149573313 hasAuthorship W2149573313A5070734184 @default.
• W2149573313 hasAuthorship W2149573313A5079232459 @default.
• W2149573313 hasAuthorship W2149573313A5086126509 @default.
• W2149573313 hasBestOaLocation W21495733132 @default.
• W2149573313 hasConcept C104317684 @default.
• W2149573313 hasConcept C143121216 @default.
• W2149573313 hasConcept C15151743 @default.
• W2149573313 hasConcept C203014093 @default.
• W2149573313 hasConcept C2776817793 @default.
• W2149573313 hasConcept C539455810 @default.
• W2149573313 hasConcept C54355233 @default.
• W2149573313 hasConcept C86803240 @default.

• next