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• W2149584528 abstract "Bisphosphonates (BPs) are widely used as the main treatment for osteoporosis. In vitro and animal studies suggest that use of BPs may have a potential for colorectal cancer (CRC) prevention. Safety and efficacy in terms of osteoporosis prevention have only been evaluated in randomized controlled trials (RCTs) of relatively short duration (3-5 years), with smaller extension studies. The evidence for a benefit beyond 5 years is limited and intake of BPs has not shown any relationship with CRC in intervention studies. Observational studies and meta-analysis have shown unchanged or decreased risk of CRC. BPs used for treatment and prevention of osteoporosis should not be applied for prevention of CRC in clinical practice." @default.
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• W2149584528 date "2015-04-22" @default.
• W2149584528 modified "2023-09-25" @default.
• W2149584528 title "Oral bisphosphonates and colon cancer: an update" @default.
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• W2149584528 doi "https://doi.org/10.1177/1759720x15582144" @default.
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