FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149587046> ?p ?o ?g. }

• W2149587046 endingPage "1177" @default.
• W2149587046 startingPage "1147" @default.
• W2149587046 abstract "This 3-mo inhalation study investigated the biological effects of a special-purpose glass microfiber (E-glass microfiber), the stone wool fiber MMVF21, and a new high-temperature application fiber (calcium-magnesium-silicate fiber, CMS) in Wistar rats. Rats were exposed 6 h/day, 5 days/wk for 3 mo to fiber aerosol concentrations of approximately 15, 50, and 150 fibers/ml (fiber length >20 microm) for E-glass microfiber and MMVF21. For the CMS fiber only the highest exposure concentration was used. During a 3-mo postexposure period, recovery effects were studied. In the highest exposure concentration groups, gravimetric concentrations were 17.2 mg/m3 for E-glass microfiber, 37 mg/m3 for MMVF21, and 49.5 mg/m3 for the CMS fiber. After 3 mo of exposure, lung retention of fibers longer than 20 micro m per lung was 17 x 10(6) for E-glass microfiber, 5.7 x 10(6) for MMVF21, and 0.88 x 10(6) for CMS. After 3 mo of recovery the concentration of the long fiber fraction was decreased to 38.4%, 63.9%, and 3.0% compared to original lung burden for the E-glass microfiber, MMVF21, and CMS, respectively. Biological effects measured included inflammatory and proliferative potential, histopathology lesions, and the persistence of these effects over a recovery period of 3 mo. Generally, observed effects were higher for E-glass microfiber when compared to MMVF21. The following clear dose-dependent effects on E-glass microfiber and MMVF21 exposure were observed as main findings of the study: increase in lung weight, in measured biochemical parameters and polymorphonuclear leukocytes (PMN) in the bronchoalveolar lavage fluid (BALF), in cell proliferation (BrdU-response) of terminal bronchiolar epithelium, and in interstitial fibrosis. The values observed in the proliferation assay on the carcinogenic E-glass microfiber indicate that this assay has an important predictive value with regards to potential carcinogenicity. Surprisingly, for the biosoluble CMS fiber, fibrogenic potential was detected in this study. The results of the CMS exposure group indicate that effects may be dominated by the presence of nonfibrous particles and that fibrosis may not be a predictor of carcinogenic activity of fiber samples, if the fiber preparation contains a significant fraction of nonfibrous particles. In summary, this study demonstrates the importance of fiber dust contamination by granular components. For future subchronic studies a longer posttreatment observation period would be advisable." @default.
• W2149587046 created "2016-06-24" @default.
• W2149587046 creator A5007571559 @default.
• W2149587046 creator A5016130556 @default.
• W2149587046 creator A5035073394 @default.
• W2149587046 creator A5042548817 @default.
• W2149587046 creator A5071063644 @default.
• W2149587046 creator A5074380018 @default.
• W2149587046 creator A5090991861 @default.
• W2149587046 date "2003-01-01" @default.
• W2149587046 modified "2023-09-29" @default.
• W2149587046 title "Calibration Study on Subchronic Inhalation Toxicity of Man-Made Vitreous Fibers in Rats" @default.
• W2149587046 cites W1982546106 @default.
• W2149587046 cites W1991335253 @default.
• W2149587046 cites W2010930000 @default.
• W2149587046 cites W2024729494 @default.
• W2149587046 cites W2040206934 @default.
• W2149587046 cites W2047148547 @default.
• W2149587046 cites W2063068982 @default.
• W2149587046 cites W2090521906 @default.
• W2149587046 cites W2102374722 @default.
• W2149587046 cites W2119816698 @default.
• W2149587046 cites W2122806458 @default.
• W2149587046 cites W2122850751 @default.
• W2149587046 cites W2128115397 @default.
• W2149587046 cites W2156719022 @default.
• W2149587046 cites W2161693075 @default.
• W2149587046 cites W2276273674 @default.
• W2149587046 doi "https://doi.org/10.1080/08958370390229843" @default.
• W2149587046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14515220" @default.
• W2149587046 hasPublicationYear "2003" @default.
• W2149587046 type Work @default.
• W2149587046 sameAs 2149587046 @default.
• W2149587046 citedByCount "22" @default.
• W2149587046 countsByYear W21495870462013 @default.
• W2149587046 countsByYear W21495870462014 @default.
• W2149587046 countsByYear W21495870462015 @default.
• W2149587046 countsByYear W21495870462018 @default.
• W2149587046 countsByYear W21495870462020 @default.
• W2149587046 countsByYear W21495870462022 @default.
• W2149587046 crossrefType "journal-article" @default.
• W2149587046 hasAuthorship W2149587046A5007571559 @default.
• W2149587046 hasAuthorship W2149587046A5016130556 @default.
• W2149587046 hasAuthorship W2149587046A5035073394 @default.
• W2149587046 hasAuthorship W2149587046A5042548817 @default.
• W2149587046 hasAuthorship W2149587046A5071063644 @default.
• W2149587046 hasAuthorship W2149587046A5074380018 @default.
• W2149587046 hasAuthorship W2149587046A5090991861 @default.
• W2149587046 hasConcept C12820456 @default.
• W2149587046 hasConcept C159985019 @default.
• W2149587046 hasConcept C177229083 @default.
• W2149587046 hasConcept C185592680 @default.
• W2149587046 hasConcept C192562407 @default.
• W2149587046 hasConcept C519885992 @default.
• W2149587046 hasConceptScore W2149587046C12820456 @default.
• W2149587046 hasConceptScore W2149587046C159985019 @default.
• W2149587046 hasConceptScore W2149587046C177229083 @default.
• W2149587046 hasConceptScore W2149587046C185592680 @default.
• W2149587046 hasConceptScore W2149587046C192562407 @default.
• W2149587046 hasConceptScore W2149587046C519885992 @default.
• W2149587046 hasIssue "12" @default.
• W2149587046 hasLocation W21495870461 @default.
• W2149587046 hasLocation W21495870462 @default.
• W2149587046 hasOpenAccess W2149587046 @default.
• W2149587046 hasPrimaryLocation W21495870461 @default.
• W2149587046 hasRelatedWork W1835257605 @default.
• W2149587046 hasRelatedWork W2033100407 @default.
• W2149587046 hasRelatedWork W2147215222 @default.
• W2149587046 hasRelatedWork W2763361682 @default.
• W2149587046 hasRelatedWork W2800266281 @default.
• W2149587046 hasRelatedWork W2899084033 @default.
• W2149587046 hasRelatedWork W2979807264 @default.
• W2149587046 hasRelatedWork W2998939317 @default.
• W2149587046 hasRelatedWork W3158314736 @default.
• W2149587046 hasRelatedWork W856755019 @default.
• W2149587046 hasVolume "15" @default.
• W2149587046 isParatext "false" @default.
• W2149587046 isRetracted "false" @default.
• W2149587046 magId "2149587046" @default.
• W2149587046 workType "article" @default.