Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149588051> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2149588051 endingPage "78" @default.
- W2149588051 startingPage "76" @default.
- W2149588051 abstract "Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive disease caused by deficiency of the lysosomal enzyme iduronate-2-sulphatase. This leads to the progressive accumulation of glycosaminoglycans in tissues throughout the body. As a result, patients may suffer from severe airway obstruction, skeletal deformities, cardiomyopathy and, in severely affected patients, there may be progressive neurological decline. Despite the early onset of signs and symptoms, diagnosis is often delayed. Until recently, treatment for MPS II has been largely palliative; however, enzyme replacement therapy with recombinant iduronate-2-sulphatase, which is produced in a human cell line and targets the underlying cause of the disease, has now been approved. Conclusion: This short review provides an overview of the natural history of MPS II and current experience of enzyme replacement therapy with idursulfase." @default.
- W2149588051 created "2016-06-24" @default.
- W2149588051 creator A5062666276 @default.
- W2149588051 date "2008-04-01" @default.
- W2149588051 modified "2023-09-23" @default.
- W2149588051 title "Enzyme replacement therapy with idursulfase in patients with mucopolysaccharidosis type II" @default.
- W2149588051 cites W1571262084 @default.
- W2149588051 cites W1598400863 @default.
- W2149588051 cites W1993027304 @default.
- W2149588051 cites W1993518098 @default.
- W2149588051 cites W2002083318 @default.
- W2149588051 cites W2050763350 @default.
- W2149588051 cites W2058795042 @default.
- W2149588051 cites W2108681631 @default.
- W2149588051 cites W2148045371 @default.
- W2149588051 cites W2411777075 @default.
- W2149588051 cites W4230830774 @default.
- W2149588051 doi "https://doi.org/10.1111/j.1651-2227.2008.00661.x" @default.
- W2149588051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18339193" @default.
- W2149588051 hasPublicationYear "2008" @default.
- W2149588051 type Work @default.
- W2149588051 sameAs 2149588051 @default.
- W2149588051 citedByCount "34" @default.
- W2149588051 countsByYear W21495880512012 @default.
- W2149588051 countsByYear W21495880512013 @default.
- W2149588051 countsByYear W21495880512014 @default.
- W2149588051 countsByYear W21495880512015 @default.
- W2149588051 countsByYear W21495880512016 @default.
- W2149588051 countsByYear W21495880512018 @default.
- W2149588051 countsByYear W21495880512020 @default.
- W2149588051 countsByYear W21495880512023 @default.
- W2149588051 crossrefType "journal-article" @default.
- W2149588051 hasAuthorship W2149588051A5062666276 @default.
- W2149588051 hasConcept C126322002 @default.
- W2149588051 hasConcept C187212893 @default.
- W2149588051 hasConcept C2776225084 @default.
- W2149588051 hasConcept C2779134260 @default.
- W2149588051 hasConcept C2779416428 @default.
- W2149588051 hasConcept C2779969927 @default.
- W2149588051 hasConcept C2910638406 @default.
- W2149588051 hasConcept C71924100 @default.
- W2149588051 hasConceptScore W2149588051C126322002 @default.
- W2149588051 hasConceptScore W2149588051C187212893 @default.
- W2149588051 hasConceptScore W2149588051C2776225084 @default.
- W2149588051 hasConceptScore W2149588051C2779134260 @default.
- W2149588051 hasConceptScore W2149588051C2779416428 @default.
- W2149588051 hasConceptScore W2149588051C2779969927 @default.
- W2149588051 hasConceptScore W2149588051C2910638406 @default.
- W2149588051 hasConceptScore W2149588051C71924100 @default.
- W2149588051 hasIssue "s457" @default.
- W2149588051 hasLocation W21495880511 @default.
- W2149588051 hasLocation W21495880512 @default.
- W2149588051 hasOpenAccess W2149588051 @default.
- W2149588051 hasPrimaryLocation W21495880511 @default.
- W2149588051 hasRelatedWork W1584581471 @default.
- W2149588051 hasRelatedWork W2111504029 @default.
- W2149588051 hasRelatedWork W2117500144 @default.
- W2149588051 hasRelatedWork W2142004142 @default.
- W2149588051 hasRelatedWork W2149588051 @default.
- W2149588051 hasRelatedWork W2404010182 @default.
- W2149588051 hasRelatedWork W247452021 @default.
- W2149588051 hasRelatedWork W3082276934 @default.
- W2149588051 hasRelatedWork W3134991594 @default.
- W2149588051 hasRelatedWork W4200201926 @default.
- W2149588051 hasVolume "97" @default.
- W2149588051 isParatext "false" @default.
- W2149588051 isRetracted "false" @default.
- W2149588051 magId "2149588051" @default.
- W2149588051 workType "article" @default.