Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149604694> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2149604694 endingPage "507" @default.
- W2149604694 startingPage "497" @default.
- W2149604694 abstract "In this study we investigated the influence of serum ultrafiltrate on the activities of azithromycin, other macrolides and unrelated antibiotics against Escherichia coli. In the presence of serum ultrafiltrate the MIC of azithromycin was decreased by 10-fold. The activities of erythromycin and roxithromycin were also enhanced, although to a lesser extent. The potentiation of activity was inhibited by divalent cations and by pre-treatment of the ultrafiltrate with trypsin. Potentiation of azithromycin activity was associated with a pH-independent, early increase in bactericidal activity and inhibition of bacterial metabolism. We postulate that low molecular weight proteinaceous components of normal human serum interact with azithromycin and other macrolides to alter the susceptibility of Gram-negative bacteria to the antibiotics, possibly through increased macrolide penetration across the bacterial cell membrane permeability barriers." @default.
- W2149604694 created "2016-06-24" @default.
- W2149604694 creator A5049271026 @default.
- W2149604694 creator A5090694666 @default.
- W2149604694 date "1992-01-01" @default.
- W2149604694 modified "2023-10-15" @default.
- W2149604694 title "Potentiation of azithromycin activity against <i>Escherichia coli</i> by human serum ultrafiltrate" @default.
- W2149604694 doi "https://doi.org/10.1093/jac/30.4.497" @default.
- W2149604694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1337068" @default.
- W2149604694 hasPublicationYear "1992" @default.
- W2149604694 type Work @default.
- W2149604694 sameAs 2149604694 @default.
- W2149604694 citedByCount "6" @default.
- W2149604694 countsByYear W21496046942012 @default.
- W2149604694 countsByYear W21496046942016 @default.
- W2149604694 countsByYear W21496046942018 @default.
- W2149604694 countsByYear W21496046942022 @default.
- W2149604694 countsByYear W21496046942023 @default.
- W2149604694 crossrefType "journal-article" @default.
- W2149604694 hasAuthorship W2149604694A5049271026 @default.
- W2149604694 hasAuthorship W2149604694A5090694666 @default.
- W2149604694 hasConcept C104317684 @default.
- W2149604694 hasConcept C185592680 @default.
- W2149604694 hasConcept C2778423520 @default.
- W2149604694 hasConcept C2778907293 @default.
- W2149604694 hasConcept C2780206985 @default.
- W2149604694 hasConcept C3019249092 @default.
- W2149604694 hasConcept C501593827 @default.
- W2149604694 hasConcept C523546767 @default.
- W2149604694 hasConcept C54355233 @default.
- W2149604694 hasConcept C547475151 @default.
- W2149604694 hasConcept C55493867 @default.
- W2149604694 hasConcept C86803240 @default.
- W2149604694 hasConcept C89423630 @default.
- W2149604694 hasConcept C98274493 @default.
- W2149604694 hasConceptScore W2149604694C104317684 @default.
- W2149604694 hasConceptScore W2149604694C185592680 @default.
- W2149604694 hasConceptScore W2149604694C2778423520 @default.
- W2149604694 hasConceptScore W2149604694C2778907293 @default.
- W2149604694 hasConceptScore W2149604694C2780206985 @default.
- W2149604694 hasConceptScore W2149604694C3019249092 @default.
- W2149604694 hasConceptScore W2149604694C501593827 @default.
- W2149604694 hasConceptScore W2149604694C523546767 @default.
- W2149604694 hasConceptScore W2149604694C54355233 @default.
- W2149604694 hasConceptScore W2149604694C547475151 @default.
- W2149604694 hasConceptScore W2149604694C55493867 @default.
- W2149604694 hasConceptScore W2149604694C86803240 @default.
- W2149604694 hasConceptScore W2149604694C89423630 @default.
- W2149604694 hasConceptScore W2149604694C98274493 @default.
- W2149604694 hasIssue "4" @default.
- W2149604694 hasLocation W21496046941 @default.
- W2149604694 hasLocation W21496046942 @default.
- W2149604694 hasOpenAccess W2149604694 @default.
- W2149604694 hasPrimaryLocation W21496046941 @default.
- W2149604694 hasRelatedWork W2006898895 @default.
- W2149604694 hasRelatedWork W2027191482 @default.
- W2149604694 hasRelatedWork W2116733702 @default.
- W2149604694 hasRelatedWork W2170780822 @default.
- W2149604694 hasRelatedWork W2354679576 @default.
- W2149604694 hasRelatedWork W2358064903 @default.
- W2149604694 hasRelatedWork W2369037096 @default.
- W2149604694 hasRelatedWork W2387362575 @default.
- W2149604694 hasRelatedWork W2401727783 @default.
- W2149604694 hasRelatedWork W3031758587 @default.
- W2149604694 hasVolume "30" @default.
- W2149604694 isParatext "false" @default.
- W2149604694 isRetracted "false" @default.
- W2149604694 magId "2149604694" @default.
- W2149604694 workType "article" @default.