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- W2149607712 abstract "5-Methylmercapto-2′-deoxyuridine (MeMUdR), a structural analogue of thymidine (TdR), inhibits herpes simplex virus type 1 production in mouse L (Lb) cells at concentrations that are not inhibitory to viral growth in monkey kidney (CV-1) cells. It is moderately toxic to Lb cells but not to CV-1 cells at a concentration that causes 95% inhibition of viral replication in Lb cells. MeMUdR is incorporated into cellular and viral deoxyribonucleic acid (DNA) in both systems, but to a significantly higher level (compared with thymidine) in Lb cells. These results indicate that MeMUdR is a substrate for enzymes leading to DNA synthesis and suggest that the biological function of herpes simplex virus type 1 DNA is impaired only when the incorporation of MeMUdR into the DNA reaches a relatively high level." @default.
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- W2149607712 date "1976-10-01" @default.
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- W2149607712 title "Differential Effects of 5-Methylmercapto-2′-Deoxyuridine on the Replication of Herpes Simplex Virus Type 1 in Two Cell Systems" @default.
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- W2149607712 doi "https://doi.org/10.1128/aac.10.4.682" @default.
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