FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149609891> ?p ?o ?g. }

• W2149609891 abstract "The choroid plexus (CP) is a highly vascularized tissue in the brain ventricles and acts as the blood-cerebrospinal fluid (CSF) barrier (BCSFB). A main function of the CP is to secrete CSF, which is accomplished by active transport of small ions and water from the blood side to the CSF side. The CP also supplies the brain with certain nutrients, hormones, and metal ions, while removing metabolites and xenobiotics from the CSF. Numerous membrane transporters are expressed in the CP in order to facilitate the solute exchange between the blood and the CSF. The solute carrier (SLC) superfamily represents a major class of transporters in the CP that constitutes the molecular mechanisms for CP function. Recently, we systematically and quantitatively examined Slc gene expression in 20 anatomically comprehensive brain areas in the adult mouse brain using high-quality in situ hybridization data generated by the Allen Brain Atlas. Here we focus our analysis on Slc gene expression at the BCSFB using previously obtained data. Of the 252 Slc genes present in the mouse brain, 202 Slc genes were found at detectable levels in the CP. Unsupervised hierarchical cluster analysis showed that the CP Slc gene expression pattern is substantially different from the other 19 analyzed brain regions. The majority of the Slc genes in the CP are expressed at low to moderate levels, whereas 28 Slc genes are present in the CP at the highest levels. These highly expressed Slc genes encode transporters involved in CSF secretion, energy production, and transport of nutrients, hormones, neurotransmitters, sulfate, and metal ions. In this review, the functional characteristics and potential importance of these Slc transporters in the CP are discussed, with particular emphasis on their localization and physiological functions at the BCSFB." @default.
• W2149609891 created "2016-06-24" @default.
• W2149609891 creator A5046791975 @default.
• W2149609891 creator A5056479716 @default.
• W2149609891 creator A5070775408 @default.
• W2149609891 date "2012-01-01" @default.
• W2149609891 modified "2023-10-14" @default.
• W2149609891 title "Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier" @default.
• W2149609891 cites W102979596 @default.
• W2149609891 cites W1495489270 @default.
• W2149609891 cites W1497641820 @default.
• W2149609891 cites W1506733947 @default.
• W2149609891 cites W1517698775 @default.
• W2149609891 cites W1522762901 @default.
• W2149609891 cites W1536331357 @default.
• W2149609891 cites W1540331610 @default.
• W2149609891 cites W1540979786 @default.
• W2149609891 cites W1554551759 @default.
• W2149609891 cites W1565425041 @default.
• W2149609891 cites W1567965797 @default.
• W2149609891 cites W1568192877 @default.
• W2149609891 cites W1604922098 @default.
• W2149609891 cites W1890244436 @default.
• W2149609891 cites W1927682269 @default.
• W2149609891 cites W1931099193 @default.
• W2149609891 cites W1952131548 @default.
• W2149609891 cites W1963630554 @default.
• W2149609891 cites W1965354700 @default.
• W2149609891 cites W1966752296 @default.
• W2149609891 cites W1966753177 @default.
• W2149609891 cites W1967534323 @default.
• W2149609891 cites W1968731447 @default.
• W2149609891 cites W1970159001 @default.
• W2149609891 cites W1971865988 @default.
• W2149609891 cites W1972644034 @default.
• W2149609891 cites W1972988611 @default.
• W2149609891 cites W1973613551 @default.
• W2149609891 cites W1973720069 @default.
• W2149609891 cites W1973870850 @default.
• W2149609891 cites W1975692580 @default.
• W2149609891 cites W1976678735 @default.
• W2149609891 cites W1978352779 @default.
• W2149609891 cites W1979158135 @default.
• W2149609891 cites W1979244090 @default.
• W2149609891 cites W1980234595 @default.
• W2149609891 cites W1980379287 @default.
• W2149609891 cites W1981090065 @default.
• W2149609891 cites W1981544624 @default.
• W2149609891 cites W1982626792 @default.
• W2149609891 cites W1986179029 @default.
• W2149609891 cites W1986830025 @default.
• W2149609891 cites W1988106461 @default.
• W2149609891 cites W1989736776 @default.
• W2149609891 cites W1990697514 @default.
• W2149609891 cites W1991896541 @default.
• W2149609891 cites W1992268803 @default.
• W2149609891 cites W1992704344 @default.
• W2149609891 cites W1994109200 @default.
• W2149609891 cites W1994383969 @default.
• W2149609891 cites W1994980249 @default.
• W2149609891 cites W1996321551 @default.
• W2149609891 cites W1998449043 @default.
• W2149609891 cites W1998741645 @default.
• W2149609891 cites W1998975673 @default.
• W2149609891 cites W1999465923 @default.
• W2149609891 cites W2000384301 @default.
• W2149609891 cites W2000845808 @default.
• W2149609891 cites W2001205881 @default.
• W2149609891 cites W2003262820 @default.
• W2149609891 cites W2003500905 @default.
• W2149609891 cites W2003537302 @default.
• W2149609891 cites W2004475905 @default.
• W2149609891 cites W2005813750 @default.
• W2149609891 cites W2006138834 @default.
• W2149609891 cites W2007169088 @default.
• W2149609891 cites W2007283880 @default.
• W2149609891 cites W2007383399 @default.
• W2149609891 cites W2008197060 @default.
• W2149609891 cites W2009111221 @default.
• W2149609891 cites W2011031456 @default.
• W2149609891 cites W2011111516 @default.
• W2149609891 cites W2014478565 @default.
• W2149609891 cites W2015747402 @default.
• W2149609891 cites W2015922413 @default.
• W2149609891 cites W2016339654 @default.
• W2149609891 cites W2017474174 @default.
• W2149609891 cites W2019420192 @default.
• W2149609891 cites W2020004545 @default.
• W2149609891 cites W2020324676 @default.
• W2149609891 cites W2020667085 @default.
• W2149609891 cites W2020849388 @default.
• W2149609891 cites W2021158571 @default.
• W2149609891 cites W2023560544 @default.
• W2149609891 cites W2025335683 @default.
• W2149609891 cites W2025381486 @default.
• W2149609891 cites W2025547429 @default.
• W2149609891 cites W2025660630 @default.
• W2149609891 cites W2026641087 @default.
• W2149609891 cites W2027303137 @default.
• W2149609891 cites W2028302590 @default.

• next