FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149610897> ?p ?o ?g. }

• W2149610897 endingPage "1387" @default.
• W2149610897 startingPage "1377" @default.
• W2149610897 abstract "House dust mite (HDM) is the major source of allergen in house dust and is strongly associated with the development of asthma. HDM can evoke a direct, nonallergic inflammatory reaction in vitro. We aimed to determine whether this apparent nonallergic, inflammatory response can be observed in a more complex in vivo setting. Vehicle, Alum or HDM (Dermatophagoides pteronyssinus 5 microg, i.p. with Alum) sensitised Brown-Norway rats were challenged intratracheally with vehicle (saline), HDM (Der p 10 microg) or heat-inactivated HDM on day 21. Lung function changes and the associated inflammatory response were evaluated. Tissue and bronchoalveolar lavage from Alum sensitised Der p challenged animals exhibited strong eosinophilia and neutrophilia associated with an early release of pro-inflammatory cytokines (interleukin-13 and 1beta, eotaxin and thymus and activation-regulated chemokine). This response was not attenuated by removal of HDM-associated protease activity. Interestingly, the vehicle sensitised group (no Alum) lacked this inflammatory response. HDM allergen evokes nonallergic airways inflammation with an inflammatory profile similar to that of the asthmatic airway. This response, independent of the protease activity of the HDM extract, appeared to be linked to prior administration of the adjuvant Alum and the subsequent increase in total immunoglobulin E. This finding could have important implications in the development of future asthma therapies." @default.
• W2149610897 created "2016-06-24" @default.
• W2149610897 creator A5006299446 @default.
• W2149610897 creator A5009275057 @default.
• W2149610897 creator A5019043835 @default.
• W2149610897 creator A5020849878 @default.
• W2149610897 creator A5032968420 @default.
• W2149610897 creator A5044677411 @default.
• W2149610897 creator A5056447696 @default.
• W2149610897 creator A5056802642 @default.
• W2149610897 creator A5090651281 @default.
• W2149610897 date "2009-10-19" @default.
• W2149610897 modified "2023-09-27" @default.
• W2149610897 title "House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?" @default.
• W2149610897 cites W1489193873 @default.
• W2149610897 cites W1491240040 @default.
• W2149610897 cites W1504820480 @default.
• W2149610897 cites W1931304499 @default.
• W2149610897 cites W1966218896 @default.
• W2149610897 cites W1971662522 @default.
• W2149610897 cites W1975190212 @default.
• W2149610897 cites W1985082984 @default.
• W2149610897 cites W1985607872 @default.
• W2149610897 cites W1986838519 @default.
• W2149610897 cites W1996955331 @default.
• W2149610897 cites W1997048122 @default.
• W2149610897 cites W2026464055 @default.
• W2149610897 cites W2028022185 @default.
• W2149610897 cites W2031307069 @default.
• W2149610897 cites W2041243178 @default.
• W2149610897 cites W2047094561 @default.
• W2149610897 cites W2052938344 @default.
• W2149610897 cites W2054188263 @default.
• W2149610897 cites W2054386434 @default.
• W2149610897 cites W2054895034 @default.
• W2149610897 cites W2072132671 @default.
• W2149610897 cites W2074389578 @default.
• W2149610897 cites W2082190868 @default.
• W2149610897 cites W2089285676 @default.
• W2149610897 cites W2096843723 @default.
• W2149610897 cites W2101664092 @default.
• W2149610897 cites W2109998671 @default.
• W2149610897 cites W2117946656 @default.
• W2149610897 cites W2124554987 @default.
• W2149610897 cites W2125045516 @default.
• W2149610897 cites W2128497538 @default.
• W2149610897 cites W2136375779 @default.
• W2149610897 cites W2137666424 @default.
• W2149610897 cites W2140657337 @default.
• W2149610897 cites W2146036781 @default.
• W2149610897 cites W2153369813 @default.
• W2149610897 cites W2160855244 @default.
• W2149610897 cites W2162817186 @default.
• W2149610897 cites W2164402028 @default.
• W2149610897 cites W2164513774 @default.
• W2149610897 cites W2320094656 @default.
• W2149610897 doi "https://doi.org/10.1183/09031936.00022908" @default.
• W2149610897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19840954" @default.
• W2149610897 hasPublicationYear "2009" @default.
• W2149610897 type Work @default.
• W2149610897 sameAs 2149610897 @default.
• W2149610897 citedByCount "40" @default.
• W2149610897 countsByYear W21496108972012 @default.
• W2149610897 countsByYear W21496108972013 @default.
• W2149610897 countsByYear W21496108972014 @default.
• W2149610897 countsByYear W21496108972015 @default.
• W2149610897 countsByYear W21496108972016 @default.
• W2149610897 countsByYear W21496108972017 @default.
• W2149610897 countsByYear W21496108972018 @default.
• W2149610897 countsByYear W21496108972019 @default.
• W2149610897 countsByYear W21496108972020 @default.
• W2149610897 countsByYear W21496108972021 @default.
• W2149610897 countsByYear W21496108972022 @default.
• W2149610897 countsByYear W21496108972023 @default.
• W2149610897 crossrefType "journal-article" @default.
• W2149610897 hasAuthorship W2149610897A5006299446 @default.
• W2149610897 hasAuthorship W2149610897A5009275057 @default.
• W2149610897 hasAuthorship W2149610897A5019043835 @default.
• W2149610897 hasAuthorship W2149610897A5020849878 @default.
• W2149610897 hasAuthorship W2149610897A5032968420 @default.
• W2149610897 hasAuthorship W2149610897A5044677411 @default.
• W2149610897 hasAuthorship W2149610897A5056447696 @default.
• W2149610897 hasAuthorship W2149610897A5056802642 @default.
• W2149610897 hasAuthorship W2149610897A5090651281 @default.
• W2149610897 hasBestOaLocation W21496108971 @default.
• W2149610897 hasConcept C126322002 @default.
• W2149610897 hasConcept C13373296 @default.
• W2149610897 hasConcept C178790620 @default.
• W2149610897 hasConcept C185592680 @default.
• W2149610897 hasConcept C203014093 @default.
• W2149610897 hasConcept C207480886 @default.
• W2149610897 hasConcept C2776042228 @default.
• W2149610897 hasConcept C2776914184 @default.
• W2149610897 hasConcept C2777714996 @default.
• W2149610897 hasConcept C2777802486 @default.
• W2149610897 hasConcept C2777961210 @default.
• W2149610897 hasConcept C2778166374 @default.
• W2149610897 hasConcept C2780510475 @default.

• next