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• W2149617982 abstract "The independent force generator and the power-stroke cross-bridge model have dominated the thinking on mechanisms of muscular contraction for nearly the past five decades. Here, we review the evolution of the cross-bridge theory from its origins as a two-state model to the current thinking of a multi-state mechanical model that is tightly coupled with the hydrolysis of ATP. Finally, we emphasize the role of skeletal muscle myosin II as a molecular motor whose actions are greatly influenced by Brownian motion. We briefly consider the conceptual idea of myosin II working as a ratchet rather than a power stroke model, an idea that is explored in detail in the companion paper." @default.
• W2149617982 created "2016-06-24" @default.
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• W2149617982 date "2002-12-01" @default.
• W2149617982 modified "2023-10-17" @default.
• W2149617982 title "Considerations on muscle contraction" @default.
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• W2149617982 doi "https://doi.org/10.1016/s1050-6411(02)00036-6" @default.
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