FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149647079> ?p ?o ?g. }

• W2149647079 endingPage "1852" @default.
• W2149647079 startingPage "1843" @default.
• W2149647079 abstract "It is known that some viruses are able to induce vigorous immune reactions. This study shows that inactivated parapoxvirus ovis (Orf virus), strain D1701 (PPVO), induces an autoregulatory cytokine response that involves the upregulation of IL-12, IL-18, IFN-gamma and other T helper 1-type cytokines and their subsequent downregulation, which is accompanied by induction of IL-4. An increase in IL-10 expression was also found in the livers of PPVO-treated mice. PPVO protects mice from lethal herpes simplex virus type 1 infection and guinea pigs from recurrent genital herpes disease. With dosages as low as 500 000 virus particles, PPVO is more potent than the current standard 3TC therapy in hepatitis B virus transgenic mice. No signs of inflammation or any other side effects were observed. PPVO induces IL-12, TNF-alpha and, together with a suboptimal concentration of Concanavalin A, IFN-gamma in human peripheral blood leukocytes as well. The principle of an autoregulatory cytokine induction by an inactivated virus might have advantages over existing immune therapies and it is concluded that inactivated PPVO should be investigated further for its potential use in antiviral therapy." @default.
• W2149647079 created "2016-06-24" @default.
• W2149647079 creator A5017128601 @default.
• W2149647079 creator A5049060150 @default.
• W2149647079 creator A5053885954 @default.
• W2149647079 creator A5067217299 @default.
• W2149647079 creator A5067549793 @default.
• W2149647079 creator A5072127887 @default.
• W2149647079 creator A5075167876 @default.
• W2149647079 creator A5090117715 @default.
• W2149647079 creator A5091590103 @default.
• W2149647079 date "2003-07-01" @default.
• W2149647079 modified "2023-10-03" @default.
• W2149647079 title "Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus" @default.
• W2149647079 cites W1495638035 @default.
• W2149647079 cites W1525530602 @default.
• W2149647079 cites W1566974294 @default.
• W2149647079 cites W1933670444 @default.
• W2149647079 cites W1975096375 @default.
• W2149647079 cites W1986003731 @default.
• W2149647079 cites W2002124880 @default.
• W2149647079 cites W2002386257 @default.
• W2149647079 cites W2004101628 @default.
• W2149647079 cites W2029489668 @default.
• W2149647079 cites W2032827845 @default.
• W2149647079 cites W2033588475 @default.
• W2149647079 cites W2034521718 @default.
• W2149647079 cites W2035199058 @default.
• W2149647079 cites W2037127090 @default.
• W2149647079 cites W2040894217 @default.
• W2149647079 cites W2067937110 @default.
• W2149647079 cites W2089332932 @default.
• W2149647079 cites W2092193247 @default.
• W2149647079 cites W2092333125 @default.
• W2149647079 cites W2115405633 @default.
• W2149647079 cites W2116248598 @default.
• W2149647079 cites W2124576546 @default.
• W2149647079 cites W2130866697 @default.
• W2149647079 cites W2136749452 @default.
• W2149647079 cites W2138195465 @default.
• W2149647079 cites W2145200173 @default.
• W2149647079 cites W2157098396 @default.
• W2149647079 cites W2335496717 @default.
• W2149647079 doi "https://doi.org/10.1099/vir.0.19138-0" @default.
• W2149647079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12810878" @default.
• W2149647079 hasPublicationYear "2003" @default.
• W2149647079 type Work @default.
• W2149647079 sameAs 2149647079 @default.
• W2149647079 citedByCount "54" @default.
• W2149647079 countsByYear W21496470792012 @default.
• W2149647079 countsByYear W21496470792013 @default.
• W2149647079 countsByYear W21496470792014 @default.
• W2149647079 countsByYear W21496470792015 @default.
• W2149647079 countsByYear W21496470792016 @default.
• W2149647079 countsByYear W21496470792017 @default.
• W2149647079 countsByYear W21496470792018 @default.
• W2149647079 countsByYear W21496470792019 @default.
• W2149647079 countsByYear W21496470792020 @default.
• W2149647079 countsByYear W21496470792021 @default.
• W2149647079 countsByYear W21496470792022 @default.
• W2149647079 countsByYear W21496470792023 @default.
• W2149647079 crossrefType "journal-article" @default.
• W2149647079 hasAuthorship W2149647079A5017128601 @default.
• W2149647079 hasAuthorship W2149647079A5049060150 @default.
• W2149647079 hasAuthorship W2149647079A5053885954 @default.
• W2149647079 hasAuthorship W2149647079A5067217299 @default.
• W2149647079 hasAuthorship W2149647079A5067549793 @default.
• W2149647079 hasAuthorship W2149647079A5072127887 @default.
• W2149647079 hasAuthorship W2149647079A5075167876 @default.
• W2149647079 hasAuthorship W2149647079A5090117715 @default.
• W2149647079 hasAuthorship W2149647079A5091590103 @default.
• W2149647079 hasBestOaLocation W21496470791 @default.
• W2149647079 hasConcept C159047783 @default.
• W2149647079 hasConcept C203014093 @default.
• W2149647079 hasConcept C2522874641 @default.
• W2149647079 hasConcept C2780593183 @default.
• W2149647079 hasConcept C2781196997 @default.
• W2149647079 hasConcept C86803240 @default.
• W2149647079 hasConcept C8891405 @default.
• W2149647079 hasConceptScore W2149647079C159047783 @default.
• W2149647079 hasConceptScore W2149647079C203014093 @default.
• W2149647079 hasConceptScore W2149647079C2522874641 @default.
• W2149647079 hasConceptScore W2149647079C2780593183 @default.
• W2149647079 hasConceptScore W2149647079C2781196997 @default.
• W2149647079 hasConceptScore W2149647079C86803240 @default.
• W2149647079 hasConceptScore W2149647079C8891405 @default.
• W2149647079 hasIssue "7" @default.
• W2149647079 hasLocation W21496470791 @default.
• W2149647079 hasLocation W21496470792 @default.
• W2149647079 hasOpenAccess W2149647079 @default.
• W2149647079 hasPrimaryLocation W21496470791 @default.
• W2149647079 hasRelatedWork W1993339219 @default.
• W2149647079 hasRelatedWork W2038801503 @default.
• W2149647079 hasRelatedWork W2055706740 @default.
• W2149647079 hasRelatedWork W2057824115 @default.
• W2149647079 hasRelatedWork W2066091494 @default.
• W2149647079 hasRelatedWork W2073329231 @default.
• W2149647079 hasRelatedWork W2102565620 @default.

• next