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- W2149659615 abstract "The lateral, basal, and central nuclei of the amygdala are part of a circuitry that instantiates many fear and anxious behaviors. One line of support indicates that immediate-early gene (IEG) expression (e.g., c-fos and egr-1 (zif268)) is increased in these nuclei following fear conditioning. Other research finds that anxiogenic drugs working through various mechanisms induce IEG expression in the central nucleus of the amygdala (CeA) suggesting that expression is a neural marker for fear and anxiety. However, several studies have also found that anxiolytic drugs induce IEG expression in the CeA. Expression of egr-1 in the CeA and lateral nucleus of the amygdala following administration of anxiolytic and anxiogenic benzodiazepine and serotonin agonists and antagonists was investigated. The first experiment determined behaviorally active anxiolytic and anxiogenic doses for two anxiogenic drugs (FG 7142 and mCPP) and two anxiolytic drugs (diazepam and buspirone). The effects of anxiogenic and anxiolytic doses of these drugs on egr-1 expression in the amygdala were then tested in a second experiment. All four drugs increased egr-1 in the CeA indicating that increased egr-1 mRNA expression in the CeA is not specific to anxiolytic or anxiogenic effects of the drugs. We suggest that IEG expression in the CeA may be due to activation of circuits that are associated with systemic physiological homeostasis perturbed by a number of drugs including anxiogenic and anxiolytic compounds." @default.
- W2149659615 created "2016-06-24" @default.
- W2149659615 creator A5020678717 @default.
- W2149659615 creator A5085388424 @default.
- W2149659615 date "2006-01-01" @default.
- W2149659615 modified "2023-10-11" @default.
- W2149659615 title "Immediate-early gene expression in the central nucleus of the amygdala is not specific for anxiolytic or anxiogenic drugs" @default.
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- W2149659615 doi "https://doi.org/10.1016/j.neuropharm.2005.07.024" @default.
- W2149659615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16185722" @default.
- W2149659615 hasPublicationYear "2006" @default.
- W2149659615 type Work @default.