Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149666434> ?p ?o ?g. }
- W2149666434 endingPage "no" @default.
- W2149666434 startingPage "no" @default.
- W2149666434 abstract "Transcriptional regulation of gene expression is thought to play a pivotal role in activity-dependent neuronal differentiation and circuit formation. Here, we investigated the role of histone deacetylase 9 (HDAC9), which regulates transcription by histone modification, in the development of neocortical neurons. The translocation of HDAC9 from nucleus to cytoplasm was induced by an increase of spontaneous firing activity in cultured mouse cortical neurons. This nucleocytoplasmic translocation was also observed in postnatal development in vivo. The translocation-induced gene expression and cellular morphology was further examined by introducing an HDAC9 mutant that disrupts the nucleocytoplasmic translocation. Expression of c-fos, an immediately-early gene, was suppressed in the mutant-transfected cells regardless of neural activity. Moreover, the introduction of the mutant decreased the total length of dendritic branches, whereas knockdown of HDAC9 promoted dendritic growth. These findings indicate that chromatin remodeling with nucleocytoplasmic translocation of HDAC9 regulates activity-dependent gene expression and dendritic growth in developing cortical neurons." @default.
- W2149666434 created "2016-06-24" @default.
- W2149666434 creator A5003042350 @default.
- W2149666434 creator A5005440384 @default.
- W2149666434 creator A5018201552 @default.
- W2149666434 creator A5032930447 @default.
- W2149666434 creator A5057581095 @default.
- W2149666434 creator A5068543524 @default.
- W2149666434 creator A5072598157 @default.
- W2149666434 creator A5088807514 @default.
- W2149666434 date "2010-04-01" @default.
- W2149666434 modified "2023-10-18" @default.
- W2149666434 title "Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons" @default.
- W2149666434 cites W1900565974 @default.
- W2149666434 cites W1947596099 @default.
- W2149666434 cites W1963806203 @default.
- W2149666434 cites W1964727943 @default.
- W2149666434 cites W1965855977 @default.
- W2149666434 cites W1974651731 @default.
- W2149666434 cites W1975410216 @default.
- W2149666434 cites W1984113114 @default.
- W2149666434 cites W1984233525 @default.
- W2149666434 cites W1989053030 @default.
- W2149666434 cites W1989576874 @default.
- W2149666434 cites W1990493528 @default.
- W2149666434 cites W1991987237 @default.
- W2149666434 cites W1992529363 @default.
- W2149666434 cites W1998977808 @default.
- W2149666434 cites W2002698073 @default.
- W2149666434 cites W2003653107 @default.
- W2149666434 cites W2005471059 @default.
- W2149666434 cites W2006154315 @default.
- W2149666434 cites W2008201324 @default.
- W2149666434 cites W2008622025 @default.
- W2149666434 cites W2010466297 @default.
- W2149666434 cites W2014764883 @default.
- W2149666434 cites W2016243020 @default.
- W2149666434 cites W2018584396 @default.
- W2149666434 cites W2022200790 @default.
- W2149666434 cites W2024126284 @default.
- W2149666434 cites W2025868352 @default.
- W2149666434 cites W2035915355 @default.
- W2149666434 cites W2042834556 @default.
- W2149666434 cites W2045815014 @default.
- W2149666434 cites W2048162805 @default.
- W2149666434 cites W2049765198 @default.
- W2149666434 cites W2050294014 @default.
- W2149666434 cites W2056108005 @default.
- W2149666434 cites W2056286291 @default.
- W2149666434 cites W2064226140 @default.
- W2149666434 cites W2065399757 @default.
- W2149666434 cites W2065585647 @default.
- W2149666434 cites W2069576017 @default.
- W2149666434 cites W2074953607 @default.
- W2149666434 cites W2076766472 @default.
- W2149666434 cites W2078299830 @default.
- W2149666434 cites W2086168922 @default.
- W2149666434 cites W2088804493 @default.
- W2149666434 cites W2092879602 @default.
- W2149666434 cites W2094455233 @default.
- W2149666434 cites W2097713433 @default.
- W2149666434 cites W2108116956 @default.
- W2149666434 cites W2128966898 @default.
- W2149666434 cites W2130413520 @default.
- W2149666434 cites W2132619798 @default.
- W2149666434 cites W2133446638 @default.
- W2149666434 cites W2139074300 @default.
- W2149666434 cites W2141882676 @default.
- W2149666434 cites W2148686253 @default.
- W2149666434 cites W2149340681 @default.
- W2149666434 cites W2161763646 @default.
- W2149666434 cites W2167799600 @default.
- W2149666434 cites W2409599842 @default.
- W2149666434 doi "https://doi.org/10.1111/j.1460-9568.2010.07218.x" @default.
- W2149666434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20525066" @default.
- W2149666434 hasPublicationYear "2010" @default.
- W2149666434 type Work @default.
- W2149666434 sameAs 2149666434 @default.
- W2149666434 citedByCount "43" @default.
- W2149666434 countsByYear W21496664342012 @default.
- W2149666434 countsByYear W21496664342013 @default.
- W2149666434 countsByYear W21496664342014 @default.
- W2149666434 countsByYear W21496664342015 @default.
- W2149666434 countsByYear W21496664342016 @default.
- W2149666434 countsByYear W21496664342017 @default.
- W2149666434 countsByYear W21496664342018 @default.
- W2149666434 countsByYear W21496664342019 @default.
- W2149666434 countsByYear W21496664342020 @default.
- W2149666434 countsByYear W21496664342021 @default.
- W2149666434 countsByYear W21496664342022 @default.
- W2149666434 countsByYear W21496664342023 @default.
- W2149666434 crossrefType "journal-article" @default.
- W2149666434 hasAuthorship W2149666434A5003042350 @default.
- W2149666434 hasAuthorship W2149666434A5005440384 @default.
- W2149666434 hasAuthorship W2149666434A5018201552 @default.
- W2149666434 hasAuthorship W2149666434A5032930447 @default.
- W2149666434 hasAuthorship W2149666434A5057581095 @default.
- W2149666434 hasAuthorship W2149666434A5068543524 @default.