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- W2149673338 abstract "Superficial fungus infections are seen in animals and humans alike. Prescription and most over-the-counter treatments act on the fungal cell wall. Whereas in humans, allylamines and azoles are now available along with griseofulvin for oral treatment of dermatophyte infections, these newer agents are not presently licensed for use in animals. At our horse farm, three ground 250 mg tablets of terbinafine given orally for 10 days proved curative in two horses with culture-positive fungal infections of their skin. Terbinifine (Lamisil Ŗ ), the only approved oral allylamine for human use, constitutes a new class of anti-dermatophyte medications that provide superior effectiveness with an extremely high safety profile. 1,2 The drug blocks squalene epoxidase in the synthesis of ergosterol, 2,3 which along with protein and phospholipid molecules, composes fungal cell membranes. Without functional ergosterol, membranes become permeable and stiffen. Terbinifine, unlike the other oral antifungals, itraconazole and griseofulvin, is fungicidal without acting via the cytochrome P-450 enzyme system. 2 Neither terbinifine or itraconazole is licensed for veterinary use. Given the superior results of the newer oral antifungals in human dermatophyte infections, we opted to test terbinifine's effectiveness on horses." @default.
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- W2149673338 date "1999-10-01" @default.
- W2149673338 modified "2023-09-26" @default.
- W2149673338 title "Dermatophytosis in horses treated with terbinafine" @default.
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- W2149673338 doi "https://doi.org/10.1016/s0737-0806(06)82200-8" @default.
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