Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149675767> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2149675767 endingPage "175" @default.
- W2149675767 startingPage "175" @default.
- W2149675767 abstract "Objective: Preclinical and very limited clinical studies suggest that sildenafil may have therapeutic potential in selected neurological disorders. However, many neurological side effects of sildenafil have been reported. This work aimed to clarify the histopathological effect of sildenafil citrate on the superior colliculus (SC) of adult male albino rat. Material and methods: 24 adult male albino rats were used and divided into 4 groups. The first 3 groups were received respectively sildenafil citrate orally at doses 0.25, 0.70 and 1.43mg/kg body weight daily for 30 days while the 4 th group was used as control. At end of the treatment, the superior colliculi were undergone light and electron microscopic investigation. Results: In the control group, superficial part of the SC has neural cells and myelinated nerve fibers. With least dose of sildenafil, the superficial part of SC revealed disturbance in neural tissue with dilated capillaries and vacuoles. Some neurons showed deeply stained nuclei shrunken cytoplasm. Some cells showed enlarged mitochondria and dilated endoplasmic reticulum. With medium dose of sildenafil, SC showed more disturbances; stripped myelin sheaths or widely separated myelin lamellae, dilated blood vessels with large vacuoles around them and many neurons with apoptotic criteria. However, maximum dose of sildenafil induced massive destruction of edematous neural tissue; invasion of the surface with massive blood vessels, marked decrease in thickness of myelin sheaths and the neural cells revealed degenerative and apoptotic changes. The mean number and size of cells revealed significantly progressive decrease in all treated rats with increasing doses of the drug. Conclusion: Long-term, daily use of sildenafil can lead to pathological effect in the superior colliculus which may be implicated in visual disturbance and this effect is dose dependent, so neurological effect of sildenafil necessitates further investigations. © 2013 GESDAV" @default.
- W2149675767 created "2016-06-24" @default.
- W2149675767 creator A5068424534 @default.
- W2149675767 creator A5073308153 @default.
- W2149675767 date "2013-01-01" @default.
- W2149675767 modified "2023-10-18" @default.
- W2149675767 title "The Histopathological Effect of Sildenafil Citrate on Superior Colliculus of Adult Male Rat" @default.
- W2149675767 cites W1503393361 @default.
- W2149675767 cites W154632621 @default.
- W2149675767 cites W1577333723 @default.
- W2149675767 cites W187336278 @default.
- W2149675767 cites W1964184415 @default.
- W2149675767 cites W1964497376 @default.
- W2149675767 cites W1978654241 @default.
- W2149675767 cites W1983310939 @default.
- W2149675767 cites W1998143238 @default.
- W2149675767 cites W2005631120 @default.
- W2149675767 cites W2020311830 @default.
- W2149675767 cites W2031753070 @default.
- W2149675767 cites W2042335373 @default.
- W2149675767 cites W2056222811 @default.
- W2149675767 cites W2081397635 @default.
- W2149675767 cites W2103593548 @default.
- W2149675767 cites W2105711200 @default.
- W2149675767 cites W2122223379 @default.
- W2149675767 cites W2123293252 @default.
- W2149675767 cites W2141627140 @default.
- W2149675767 cites W2142151523 @default.
- W2149675767 cites W2157380583 @default.
- W2149675767 cites W2157410362 @default.
- W2149675767 cites W2162722262 @default.
- W2149675767 cites W2182199980 @default.
- W2149675767 cites W2324155785 @default.
- W2149675767 cites W2327323427 @default.
- W2149675767 cites W2338539879 @default.
- W2149675767 cites W2406062456 @default.
- W2149675767 cites W2497432837 @default.
- W2149675767 cites W351914998 @default.
- W2149675767 cites W89410669 @default.
- W2149675767 doi "https://doi.org/10.5455/jihp.20130419092832" @default.
- W2149675767 hasPublicationYear "2013" @default.
- W2149675767 type Work @default.
- W2149675767 sameAs 2149675767 @default.
- W2149675767 citedByCount "2" @default.
- W2149675767 countsByYear W21496757672017 @default.
- W2149675767 crossrefType "journal-article" @default.
- W2149675767 hasAuthorship W2149675767A5068424534 @default.
- W2149675767 hasAuthorship W2149675767A5073308153 @default.
- W2149675767 hasConcept C126322002 @default.
- W2149675767 hasConcept C2776768464 @default.
- W2149675767 hasConcept C2992926266 @default.
- W2149675767 hasConcept C42407357 @default.
- W2149675767 hasConcept C71924100 @default.
- W2149675767 hasConceptScore W2149675767C126322002 @default.
- W2149675767 hasConceptScore W2149675767C2776768464 @default.
- W2149675767 hasConceptScore W2149675767C2992926266 @default.
- W2149675767 hasConceptScore W2149675767C42407357 @default.
- W2149675767 hasConceptScore W2149675767C71924100 @default.
- W2149675767 hasIssue "4" @default.
- W2149675767 hasLocation W21496757671 @default.
- W2149675767 hasOpenAccess W2149675767 @default.
- W2149675767 hasPrimaryLocation W21496757671 @default.
- W2149675767 hasRelatedWork W1975064923 @default.
- W2149675767 hasRelatedWork W1989870400 @default.
- W2149675767 hasRelatedWork W2006206929 @default.
- W2149675767 hasRelatedWork W2889529591 @default.
- W2149675767 hasRelatedWork W2953633878 @default.
- W2149675767 hasRelatedWork W2981515574 @default.
- W2149675767 hasRelatedWork W3015963997 @default.
- W2149675767 hasRelatedWork W3159891967 @default.
- W2149675767 hasRelatedWork W4232428403 @default.
- W2149675767 hasRelatedWork W1925451480 @default.
- W2149675767 hasVolume "1" @default.
- W2149675767 isParatext "false" @default.
- W2149675767 isRetracted "false" @default.
- W2149675767 magId "2149675767" @default.
- W2149675767 workType "article" @default.