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• W2149676696 abstract "Oleifolioside A, a new triterpenoid compound isolated from Dendropanax morbifera Leveille ( D. morbifera ), was shown in this study to have potent inhibitory effects on lipopolysaccharide (LPS-)stimulated nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) production in RAW 264.7 macrophages. Consistent with these findings, oleifolioside A was further shown to suppress the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and cyclooxigenase-2 (COX-2) in a dose-dependent manner at both the protein and mRNA levels and to significantly inhibit the DNA-binding activity and transcriptional activity of NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B in response to LPS. These results were found to be associated with the inhibition of the degradation and phosphorylation of I<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>and subsequent translocation of the NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B p65 subunit to the nucleus. Inhibition of NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B activation by oleifolioside A was also shown to be mediated through the prevention of p38 MAPK and ERK1/2 phosphorylation. Taken together, our results suggest that oleifolioside A has the potential to be a novel anti-inflammatory agent capable of targeting both the NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B and MAPK signaling pathways." @default.
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• W2149676696 title "Oleifolioside A, a New Active Compound, Attenuates LPS-Stimulated iNOS and COX-2 Expression through the Downregulation of NF-<i>κ</i>B and MAPK Activities in RAW 264.7 Macrophages" @default.
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• W2149676696 doi "https://doi.org/10.1155/2012/637512" @default.
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