FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149679599> ?p ?o ?g. }

• W2149679599 endingPage "1054" @default.
• W2149679599 startingPage "1048" @default.
• W2149679599 abstract "ABSTRACT HLA class I alleles have been shown to have differential impacts on the viral load and the outcome of HIV-1 disease progression. In this study, HLA class I types from residents of China with acute HIV-1 infection, diagnosed between 2006 and 2011, were identified and the association between expression of individual HLA alleles and the level of the set point viral load was analyzed. A lower level of set point viral load was found to be associated with the Bw4 homozygote on HLA-B alleles. B*44 and B*57 alleles have also been found to be associated with lower set point viral load. The set point viral load of B*44-positive individuals homozygous for Bw4 was significantly lower than that of B*44-negative individuals homozygous for Bw4 ( P = 0.030). The CD4 count declined to <350 in fewer B*44-positive individuals than B*44-negative individuals ( X 2 = 7.295, P = 0.026). B*44-positive individuals had a lower magnitude of p24 pool-specific T cell responses than B*44-negative individuals homozygous for Bw4, though this was not statistically significant. The p24 pool-specific T cell responses were also inversely correlated with lower viral load ( r s = −0.88, P = 0.033). Six peptides within p24 were recognized to induce the specific-T cell response in B*44-positive individuals, and the peptide breadth of response was same as that in B*44-negative individuals homozygous for Bw4, but the median magnitude of specific-T cell responses to the recognized peptides in B*44-positive individuals was lower than that in B*44-negative individuals homozygous for Bw4 ( P = 0.049). These findings imply that weak p24-specific CD8 + T cell responses might play an important role in the control of HIV viremia in B*44 allele-positive individuals. Such studies might contribute to the development of future therapeutic strategies that take into account the genetic background of the patients." @default.
• W2149679599 created "2016-06-24" @default.
• W2149679599 creator A5001999511 @default.
• W2149679599 creator A5006651636 @default.
• W2149679599 creator A5007734558 @default.
• W2149679599 creator A5027923750 @default.
• W2149679599 creator A5052022256 @default.
• W2149679599 creator A5053027137 @default.
• W2149679599 creator A5058186904 @default.
• W2149679599 creator A5068505151 @default.
• W2149679599 date "2013-05-15" @default.
• W2149679599 modified "2023-10-10" @default.
• W2149679599 title "HLA-B*44 Is Associated with a Lower Viral Set Point and Slow CD4 Decline in a Cohort of Chinese Homosexual Men Acutely Infected with HIV-1" @default.
• W2149679599 cites W1971877271 @default.
• W2149679599 cites W1982024820 @default.
• W2149679599 cites W1985040687 @default.
• W2149679599 cites W1988933769 @default.
• W2149679599 cites W1995118547 @default.
• W2149679599 cites W2001534465 @default.
• W2149679599 cites W2004675438 @default.
• W2149679599 cites W2008104868 @default.
• W2149679599 cites W2008633460 @default.
• W2149679599 cites W2011541285 @default.
• W2149679599 cites W2012139740 @default.
• W2149679599 cites W2033654955 @default.
• W2149679599 cites W2035555649 @default.
• W2149679599 cites W2045551237 @default.
• W2149679599 cites W2051470841 @default.
• W2149679599 cites W2055779317 @default.
• W2149679599 cites W2058321555 @default.
• W2149679599 cites W2059332413 @default.
• W2149679599 cites W2061763109 @default.
• W2149679599 cites W2064883226 @default.
• W2149679599 cites W2070539000 @default.
• W2149679599 cites W2076225720 @default.
• W2149679599 cites W2104683876 @default.
• W2149679599 cites W2118619247 @default.
• W2149679599 cites W2123584222 @default.
• W2149679599 cites W2126141460 @default.
• W2149679599 cites W2128306333 @default.
• W2149679599 cites W2142405752 @default.
• W2149679599 cites W2155844694 @default.
• W2149679599 cites W2156430803 @default.
• W2149679599 cites W2157824753 @default.
• W2149679599 cites W2161290118 @default.
• W2149679599 doi "https://doi.org/10.1128/cvi.00015-13" @default.
• W2149679599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3697455" @default.
• W2149679599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23677320" @default.
• W2149679599 hasPublicationYear "2013" @default.
• W2149679599 type Work @default.
• W2149679599 sameAs 2149679599 @default.
• W2149679599 citedByCount "10" @default.
• W2149679599 countsByYear W21496795992015 @default.
• W2149679599 countsByYear W21496795992017 @default.
• W2149679599 countsByYear W21496795992018 @default.
• W2149679599 countsByYear W21496795992019 @default.
• W2149679599 countsByYear W21496795992023 @default.
• W2149679599 crossrefType "journal-article" @default.
• W2149679599 hasAuthorship W2149679599A5001999511 @default.
• W2149679599 hasAuthorship W2149679599A5006651636 @default.
• W2149679599 hasAuthorship W2149679599A5007734558 @default.
• W2149679599 hasAuthorship W2149679599A5027923750 @default.
• W2149679599 hasAuthorship W2149679599A5052022256 @default.
• W2149679599 hasAuthorship W2149679599A5053027137 @default.
• W2149679599 hasAuthorship W2149679599A5058186904 @default.
• W2149679599 hasAuthorship W2149679599A5068505151 @default.
• W2149679599 hasBestOaLocation W21496795991 @default.
• W2149679599 hasConcept C104317684 @default.
• W2149679599 hasConcept C127413603 @default.
• W2149679599 hasConcept C133731056 @default.
• W2149679599 hasConcept C142462285 @default.
• W2149679599 hasConcept C147483822 @default.
• W2149679599 hasConcept C159047783 @default.
• W2149679599 hasConcept C180754005 @default.
• W2149679599 hasConcept C188280979 @default.
• W2149679599 hasConcept C203014093 @default.
• W2149679599 hasConcept C2910492473 @default.
• W2149679599 hasConcept C2993627981 @default.
• W2149679599 hasConcept C3013748606 @default.
• W2149679599 hasConcept C41007239 @default.
• W2149679599 hasConcept C54355233 @default.
• W2149679599 hasConcept C86803240 @default.
• W2149679599 hasConceptScore W2149679599C104317684 @default.
• W2149679599 hasConceptScore W2149679599C127413603 @default.
• W2149679599 hasConceptScore W2149679599C133731056 @default.
• W2149679599 hasConceptScore W2149679599C142462285 @default.
• W2149679599 hasConceptScore W2149679599C147483822 @default.
• W2149679599 hasConceptScore W2149679599C159047783 @default.
• W2149679599 hasConceptScore W2149679599C180754005 @default.
• W2149679599 hasConceptScore W2149679599C188280979 @default.
• W2149679599 hasConceptScore W2149679599C203014093 @default.
• W2149679599 hasConceptScore W2149679599C2910492473 @default.
• W2149679599 hasConceptScore W2149679599C2993627981 @default.
• W2149679599 hasConceptScore W2149679599C3013748606 @default.
• W2149679599 hasConceptScore W2149679599C41007239 @default.
• W2149679599 hasConceptScore W2149679599C54355233 @default.
• W2149679599 hasConceptScore W2149679599C86803240 @default.
• W2149679599 hasIssue "7" @default.

• next