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• W2149684906 abstract "Incorporation of fluorine at the 4-position of an existing series of sulfonyl piperidine 5-HT2A antagonists gave compounds with increased selectivity over the IKr potassium channel. This work led to the identification of 3b, a compound that gave no increase in QTc in the anesthetized dog up to plasma levels as high as 148 microM. Furthermore, 3b has been shown to increase slow-wave sleep bout duration and to decrease the number of awakenings in rats, indicating the potential utility of 5-HT2A antagonists in the treatment of insomnia." @default.
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• W2149684906 date "2005-08-01" @default.
• W2149684906 modified "2023-09-27" @default.
• W2149684906 title "4-Fluorosulfonylpiperidines: Selective 5-HT2A ligands for the treatment of insomnia" @default.
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• W2149684906 doi "https://doi.org/10.1016/j.bmcl.2005.05.104" @default.
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