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• W2149687006 abstract "Aneuploidy screening in human preimplantation embryos or preimplantation genetic screening (PGS) has been clinically applied to different groups of IVF patients for over a decade but is generally considered too invasive and inaccurate for routine embryo selection following IVF. Nevertheless, for some women (e.g. those of advanced maternal age), high incidence of aneuploidy arising in female meiosis is clearly a major factor contributing to pregnancy failure, and PGS could still have a role in their clinical management. PGS should be considered a diagnostic procedure incorporating confirmatory molecular cytogenetic analysis of any screened embryos remaining after transfer. Consequently, patients benefit from detailed assessment of aneuploidy risk and avoid transfer of aneuploid embryos. To become a successful routine adjunct for all IVF patients, PGS must tip the cost-benefit ratio towards benefit by providing: (a) safer biopsy or non-invasive methods, (b) rapid testing at low cost (c) high accuracy, (d) comprehensive analysis of all chromosomes and (e) information to distinguish between chromosomal abnormalities of meiotic and mitotic origin." @default.
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• W2149687006 date "2009-01-01" @default.
• W2149687006 modified "2023-09-24" @default.
• W2149687006 title "The Role of Aneuploidy Screening in Human Preimplantation Embryos" @default.
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• W2149687006 doi "https://doi.org/10.1007/978-1-60327-392-3_19" @default.
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