FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149687312> ?p ?o ?g. }

• W2149687312 endingPage "5192" @default.
• W2149687312 startingPage "5187" @default.
• W2149687312 abstract "In hippocampal pyramidal cells, dopamine acts at D1 receptors to reduce peak Na + currents by activation of phosphorylation by PKA anchored via an A kinase-anchoring protein (AKAP15). However, the mechanism by which AKAP15 anchors PKA to neuronal Na + channels is not known. By using a strategy of coimmunoprecipitation from transfected tsA-201 cells, we have found that AKAP15 directly interacts with Na v 1.2a channels via the intracellular loop between domains I and II. This loop contains key functional phosphorylation sites. Mutagenesis indicated that this interaction occurs through a modified leucine zipper motif near the N terminus of the loop. Whole-cell patch clamp recordings of acutely dissociated hippocampal pyramidal cells revealed that the D1 dopamine receptor agonist SKF 81297 reduces peak Na + current amplitude by 20.5%, as reported previously. Disruption of the leucine zipper interaction between Na v 1.2a and AKAP15 through the inclusion of a small competing peptide in the patch pipette inhibited the SKF 81297-induced reduction in peak Na + current, whereas a control peptide with mutations in amino acids important for the leucine zipper interaction did not. Our results define the molecular mechanism by which G protein-coupled signaling pathways can rapidly and efficiently modulate neuronal excitability through local protein phosphorylation of Na + channels by specifically anchored PKA." @default.
• W2149687312 created "2016-06-24" @default.
• W2149687312 creator A5002307585 @default.
• W2149687312 creator A5033554919 @default.
• W2149687312 creator A5078941732 @default.
• W2149687312 date "2007-03-20" @default.
• W2149687312 modified "2023-09-25" @default.
• W2149687312 title "Dopamine modulation of neuronal Na ⁺ channels requires binding of A kinase-anchoring protein 15and PKA by a modified leucine zipper motif" @default.
• W2149687312 cites W1487738788 @default.
• W2149687312 cites W1492344127 @default.
• W2149687312 cites W1530102523 @default.
• W2149687312 cites W1533711314 @default.
• W2149687312 cites W1538429608 @default.
• W2149687312 cites W1581529107 @default.
• W2149687312 cites W1591245254 @default.
• W2149687312 cites W1596672035 @default.
• W2149687312 cites W1630525523 @default.
• W2149687312 cites W1662259084 @default.
• W2149687312 cites W1665323890 @default.
• W2149687312 cites W1968130118 @default.
• W2149687312 cites W1977892054 @default.
• W2149687312 cites W1977984619 @default.
• W2149687312 cites W1980495789 @default.
• W2149687312 cites W1981327350 @default.
• W2149687312 cites W1983396112 @default.
• W2149687312 cites W1986116780 @default.
• W2149687312 cites W1994094702 @default.
• W2149687312 cites W1997155353 @default.
• W2149687312 cites W2004094484 @default.
• W2149687312 cites W2005393972 @default.
• W2149687312 cites W2010822247 @default.
• W2149687312 cites W2024645073 @default.
• W2149687312 cites W2024732013 @default.
• W2149687312 cites W2039072874 @default.
• W2149687312 cites W2044375195 @default.
• W2149687312 cites W2044603696 @default.
• W2149687312 cites W2049699715 @default.
• W2149687312 cites W2053215679 @default.
• W2149687312 cites W2055864348 @default.
• W2149687312 cites W2060451219 @default.
• W2149687312 cites W2060799754 @default.
• W2149687312 cites W2097761188 @default.
• W2149687312 cites W2099753276 @default.
• W2149687312 cites W2100977258 @default.
• W2149687312 cites W2102443549 @default.
• W2149687312 cites W2115044183 @default.
• W2149687312 cites W2131075809 @default.
• W2149687312 cites W2137042012 @default.
• W2149687312 cites W2160468101 @default.
• W2149687312 cites W2165633817 @default.
• W2149687312 cites W2169064772 @default.
• W2149687312 cites W2171273632 @default.
• W2149687312 cites W2394552110 @default.
• W2149687312 cites W2405185874 @default.
• W2149687312 cites W4243228481 @default.
• W2149687312 cites W4300374597 @default.
• W2149687312 doi "https://doi.org/10.1073/pnas.0611619104" @default.
• W2149687312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1829284" @default.
• W2149687312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17360357" @default.
• W2149687312 hasPublicationYear "2007" @default.
• W2149687312 type Work @default.
• W2149687312 sameAs 2149687312 @default.
• W2149687312 citedByCount "49" @default.
• W2149687312 countsByYear W21496873122012 @default.
• W2149687312 countsByYear W21496873122014 @default.
• W2149687312 countsByYear W21496873122015 @default.
• W2149687312 countsByYear W21496873122016 @default.
• W2149687312 countsByYear W21496873122017 @default.
• W2149687312 countsByYear W21496873122018 @default.
• W2149687312 countsByYear W21496873122020 @default.
• W2149687312 countsByYear W21496873122021 @default.
• W2149687312 countsByYear W21496873122022 @default.
• W2149687312 countsByYear W21496873122023 @default.
• W2149687312 crossrefType "journal-article" @default.
• W2149687312 hasAuthorship W2149687312A5002307585 @default.
• W2149687312 hasAuthorship W2149687312A5033554919 @default.
• W2149687312 hasAuthorship W2149687312A5078941732 @default.
• W2149687312 hasBestOaLocation W21496873121 @default.
• W2149687312 hasConcept C104317684 @default.
• W2149687312 hasConcept C11960822 @default.
• W2149687312 hasConcept C12554922 @default.
• W2149687312 hasConcept C147944092 @default.
• W2149687312 hasConcept C156860981 @default.
• W2149687312 hasConcept C169760540 @default.
• W2149687312 hasConcept C170493617 @default.
• W2149687312 hasConcept C185592680 @default.
• W2149687312 hasConcept C2778938600 @default.
• W2149687312 hasConcept C513476851 @default.
• W2149687312 hasConcept C55493867 @default.
• W2149687312 hasConcept C86339819 @default.
• W2149687312 hasConcept C86803240 @default.
• W2149687312 hasConcept C95444343 @default.
• W2149687312 hasConcept C97029542 @default.
• W2149687312 hasConceptScore W2149687312C104317684 @default.
• W2149687312 hasConceptScore W2149687312C11960822 @default.
• W2149687312 hasConceptScore W2149687312C12554922 @default.
• W2149687312 hasConceptScore W2149687312C147944092 @default.
• W2149687312 hasConceptScore W2149687312C156860981 @default.

• next